Nystatin | CAS No. 1400-61-9

Nystatin

Basic Information

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CAS Number

1400-61-9

Molecular Formula

C47H75NO17

Molecular Weight

926.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

>155°C (dec.)

Boiling Point

476°Cat760mmHg

Density

1.31 g/cm3

Flash Point

127.3°C

Solubility

H2O: insoluble

Refractive Index

1.503

Specific Rotation

D25 -10° (glacial acetic acid); +21° (pyridine); +12° (DMF); -7° (0.1N HCl in methanol)

SMILES

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CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

InChI

InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1

InChIKey

VQOXZBDYSJBXMA-RKEBNKJGSA-N

LogP

1.47860

Complexity

1620

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Toxicity

LD50 i.p. in mice: ~200 mg/kg (Seneca)

Synonyms & References

English

EN300-19639979
Nystatine [INN-French]
AV & NYS
Stamycin
Mycostatin Pastilles
DB00646
Nystatine
Nystan
(1S,15S,16R,17R,18S)-33-{[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
Nystex
Moronal (antibiotic)
Nyotran
Candex Lotion
Nystatinum
Mykostatyna
1400-61-9
UNII-BDF1O1C72E
AKOS016339654
NSC 150817
(4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid
Nystatin LF (liposome)
Herniocid
Nystatin [USP:INN:BAN:JAN]
HSDB 3138
nystatin
Terrastatin
Biofanal
KS-1373
EPA Pesticide Chemical Code 202800
EINECS 215-749-0
SCHEMBL284974

MDL Number

MFCD27989284

Customs Code

2942000000

FAQ

What is Nystatin (CAS: 1400-61-9)?

Nystatin (CAS: 1400-61-9) is a polyene antifungal medication used to treat fungal infections. It has the chemical formula C43H72N10O14 and is a white to pale yellow powder. Nystatin works by binding to ergosterol in fungal cell membranes, disrupting their integrity and inhibiting growth. It is commonly used in topical formulations for conditions like candidiasis and oral thrush.

What are the main uses of Nystatin (CAS: 1400-61-9)?

Nystatin (CAS: 1400-61-9) is primarily used as an antifungal agent in pharmaceuticals to treat infections caused by Candida species. It is available in topical creams, oral suspensions, and vaginal suppositories. Additionally, it is used in veterinary medicine and as a food additive in some countries to control fungal contamination in agricultural products.

Is Nystatin (CAS: 1400-61-9) safe?

Nystatin (CAS: 1400-61-9) is generally safe when used as directed, with minimal systemic absorption. It is considered non-toxic for topical application but should be handled with care to avoid inhalation or ingestion. Safety standards include FDA approval for medicinal use, and protective measures like gloves are recommended during preparation or handling to ensure user safety.

How should Nystatin (CAS: 1400-61-9) be stored?

Nystatin (CAS: 1400-61-9) should be stored in a cool, dry place (15-30°C) away from moisture and direct light. Keep the container tightly sealed to maintain stability and prevent contamination. Proper storage ensures the medication remains effective and adheres to pharmaceutical quality standards for extended use.