16α-Hydroxyprednisolone

Basic Information

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CAS Number

13951-70-7

Molecular Formula

C21H28O6

Molecular Weight

376.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

245-250°C

Boiling Point

591.5℃ at 760 mmHg

Specific Rotation

+74.0° - +80.0° (c=1, MeOH)

SMILES

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CC12CC(C3C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC34C)O

InChI

InChI=1S/C21H28O6/c1-19-6-5-12(23)7-11(19)3-4-13-14-8-16(25)21(27,17(26)10-22)20(14,2)9-15(24)18(13)19/h5-7,13-16,18,22,24-25,27H,3-4,8-10H2,1-2H3/t13-,14-,15-,16+,18+,19-,20-,21-/m0/s1

InChIKey

SEKYBDYVXDAYPY-ILNISADRSA-N

LogP

0.5284000000000002

Topological Polar Surface Area

115.06000000000002 Å²

Hydrogen Bond Donor/Acceptor

4 / 6

Complexity

756

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11.beta.,16.alpha.)-
A-Hydroxyprednisolone
Q27289433
CHEMBL3542319
(11?,16?)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
AKOS025286083
BUDESONIDE IMPURITY A [EP IMPURITY]
Q-101381
(9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
SEKYBDYVXDAYPY-ILNISADRSA-N
BCP0726000097
(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
A-hydroxy-prednisolone
16alpha-Hydroxy-prednisonlone
EC 237-731-1
SCHEMBL145096
11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione; Budesonide Imp. A (EP); 16alpha-Hydroxyprednisolone; Budesonide Impurity A
AC1111
DTXSID20930496
BCP9000061
SW97540DC2
16alpha-Hydroxyprednisolone
Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11beta,16alpha)-
13951-70-7
UNII-SW97540DC2
16alpha-Hydroxyprednisolone (11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione)
16
C21H28O6
BCP04133
11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

MDL Number

MFCD00872019

Customs Code

2937210000

FAQ

What is 16α-Hydroxyprednisolone (CAS: 13951-70-7)?

16α-Hydroxyprednisolone (CAS: 13951-70-7) is a corticosteroid compound with the chemical formula C21H28O7. It is a metabolite of prednisolone and exhibits anti-inflammatory and immunosuppressive properties, commonly used in medical research and pharmaceutical applications related to corticosteroid therapy.

What are the main uses of 16α-Hydroxyprednisolone (CAS: 13951-70-7)?

16α-Hydroxyprednisolone (CAS: 13951-70-7) is primarily used in pharmaceutical research as a precursor for synthesizing other corticosteroids. It also serves in veterinary medicine for treating inflammatory conditions and in biochemical studies to investigate steroid metabolism and biological activity.

Is 16α-Hydroxyprednisolone (CAS: 13951-70-7) safe?

16α-Hydroxyprednisolone (CAS: 13951-70-7) is generally considered safe when handled properly, but it may pose risks with prolonged exposure. Safety guidelines recommend using protective equipment, avoiding inhalation, and following ICH regulations. It is classified as a controlled substance due to its potential for misuse and side effects.

How should 16α-Hydroxyprednisolone (CAS: 13951-70-7) be stored?

16α-Hydroxyprednisolone (CAS: 13951-70-7) should be stored in a cool, dry place (15-30°C), protected from light and moisture. Use airtight containers to maintain stability and prevent degradation. Proper storage ensures product integrity and adherence to pharmaceutical safety standards.