Candesartan Cilexetil EP Impurity I

Basic Information

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CAS Number

139481-69-9

Molecular Formula

C25H22N6O3

Molecular Weight

454.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

169-173°C

SMILES

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CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC

InChI

InChI=1S/C25H22N6O3/c1-3-34-25-26-21-10-6-9-20(24(32)33-2)22(21)31(25)15-16-11-13-17(14-12-16)18-7-4-5-8-19(18)23-27-29-30-28-23/h4-14H,3,15H2,1-2H3,(H,27,28,29,30)

InChIKey

RBPFEPGTRLLUKI-UHFFFAOYSA-N

LogP

4.117000000000003

Topological Polar Surface Area

107.81000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

675

Synonyms & References

English

Ethyl-2-ethoxy-1-[[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole]-7-carboxylate
Q27284852
methyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
RBPFEPGTRLLUKI-UHFFFAOYSA-N
Candesartan Methyl Ester
methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate
DS-12084
Methyl 1-[[2 inverted exclamation mark -(5-Tetrazolyl)-4-biphenylyl]methyl]-2-ethoxybenzimidazole-7-carboxylate
NG25Z8EW4V
Methyl 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylate
Methyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
MFCD18379253
SY269620
Methyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxybenzimidazole-7-carboxylate
Candesartan-d5MethylEster
NS00024508
DTXSID60161060
Methyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
2-Ethoxy-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester
Methyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (Candesartan Methyl Ester)
Methyl 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)benzimidazole-7-carboxylate
AKOS015900107
139481-69-9
(+/-)-Methyl 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)benzimidazole-7-carboxylate
CS-0151434
Methyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
Candesartan cilexetil impurity I [EP]
CANDESARTAN CILEXETIL IMPURITY I [EP IMPURITY]
Methyl 2-ethoxy-1-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
MFCD09263633
BDBM50044396

MDL Number

MFCD09263633

FAQ

What are the physical and chemical properties of Candesartan Cilexetil EP Impurity I (CAS: 139481-69-9)?

Candesartan Cilexetil EP Impurity I is a crystalline compound with a molecular weight of approximately 414.5 g/mol. It has low solubility in water but is more soluble in organic solvents. Chemically, it is stable under normal conditions but may react with strong acids or bases.

How is Candesartan Cilexetil EP Impurity I (CAS: 139481-69-9) typically synthesized?

Candesartan Cilexetil EP Impurity I is typically synthesized through a multi-step process involving organic synthesis techniques. Commonly, it involves reactions such as esterification and then subsequent purification steps. The synthesis uses common reagents and catalysts like acid catalysts and bases, with high selectivity and yield achievable under optimal conditions.

What industries use Candesartan Cilexetil EP Impurity I (CAS: 139481-69-9)?

Candesartan Cilexetil EP Impurity I is primarily used in the pharmaceutical industry as an intermediate in the production of candesartan cilexetil, a medication used to treat hypertension and heart failure. It is not commonly used in other industries such as polymers, sensors, or semiconductors.

What precautions should be taken when handling Candesartan Cilexetil EP Impurity I (CAS: 139481-69-9)?

When handling Candesartan Cilexetil EP Impurity I, it is important to use personal protective equipment (PPE) such as gloves and goggles to protect against skin and eye contact. It should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, it should be carefully cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.