Azilsartan Impurity 1

Basic Information

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CAS Number

139481-44-0

Molecular Formula

C25H21N3O3

Molecular Weight

411.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Boiling Point

630.4°C at 760 mmHg

Density

1.205

Flash Point

335.064 ºC

Refractive Index

1.619

SMILES

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CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C#N)C(=O)OC

InChI

InChI=1S/C25H21N3O3/c1-3-31-25-27-22-10-6-9-21(24(29)30-2)23(22)28(25)16-17-11-13-18(14-12-17)20-8-5-4-7-19(20)15-26/h4-14H,3,16H2,1-2H3

InChIKey

KSXLHOFDCDKQLH-UHFFFAOYSA-N

LogP

4.80858

Complexity

654

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

3-(2'-Cyano-biphenyl-4-ylmethyl)-2-ethoxy-3H-benzoimidazole-4-carboxylic acid methyl ester
A807544
Methyl 1-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate
methyl 1-({2'-cyano-[1,1'-biphenyl]-4-yl}methyl)-2-ethoxy-1H-1,3-benzodiazole-7-carboxylate
CS-0151435
Methyl 1[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate
Methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
Methyl 1-((2'-cyanobiphenyl-4-yl) methyl)-2-ethoxy-1H-benzimidazole-7-carboxylate
EC 604-137-2
Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate
CX1031
1-[[2'-cyano-biphenyl-4-yl] methyl]-2-ethoxy-1h-benzimidazole-7-carboxylate methyl ester
DTXSID80576394
Methyl 1-((2'-cyanobiphenyl-4-yl)methyl)-2-ethoxy-1H-benzimidazole-7-carboxylate
Methyl-1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate
Methyl 1-[(2'-Cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate
SCHEMBL3976108
methyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxy-benzimidazole-4-carboxylate
3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxy-4-benzimidazolecarboxylic acid methyl ester
Methyl 1-[(2'-Cyano-[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
1-[(2'-Cyano-1,1'-biphenyl-4-yl)methyl]-2-ethoxy-d5-7-benzimidazolecarboxylicAcidMethylEster
methyl 1-[(2'-cyanobiphenyl-4-yl)-methyl]-2-ethoxybenzimidazole-7-carboxylate
Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate
NS00001069
AC-7777
Methyl 1-((2'-cyano-[1 pound not1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
KSXLHOFDCDKQLH-UHFFFAOYSA-N
AKOS015896142
1H-Benzimidazole-7-carboxylic acid, 1-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-, methyl ester
1H-Benzimidazole-7-carboxylicacid,1-[(2 inverted exclamation mark -cyano[1,1 inverted exclamation mark -biphenyl]-4-yl)methyl]-2-ethoxy-,methyl ester
1H-Benzimidazole-7-carboxylicacid, 1-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-methylester

MDL Number

MFCD09031384

Customs Code

2933990090

FAQ

What is Azilsartan Impurity 1 (CAS: 139481-44-0)?

Azilsartan Impurity 1 (CAS 139481-44-0) is a specific byproduct or contaminant identified during the synthesis of Azilsartan, an angiotensin II receptor blocker used in hypertension treatment. It is classified as a pharmaceutical impurity and is typically analyzed to ensure drug purity and compliance with regulatory standards. Its chemical structure and properties are critical for quality control in drug development.

What are the main uses of Azilsartan Impurity 1 (CAS: 139481-44-0)?

Azilsartan Impurity 1 (CAS 139481-44-0) is primarily used in pharmaceutical research and quality control to identify and quantify impurities in Azilsartan drug substances. It plays a role in ensuring safety, efficacy, and regulatory compliance during drug manufacturing. It may also be used in analytical testing for method validation and impurity profiling in drug development processes.

Is Azilsartan Impurity 1 (CAS: 139481-44-0) safe?

Azilsartan Impurity 1 (CAS 139481-44-0) is not intended for therapeutic use but is considered safe when handled according to standard laboratory protocols. Safety precautions include wearing personal protective equipment (PPE) and following guidelines to minimize exposure. Its toxicity data suggests low risk under controlled conditions, though specific safety standards depend on regulatory requirements and handling practices.

How should Azilsartan Impurity 1 (CAS: 139481-44-0) be stored?

Azilsartan Impurity 1 (CAS 139481-44-0) should be stored in a cool, dry place away from light, ideally at 2-8°C. It requires a sealed container to maintain stability and prevent moisture contamination. Proper storage ensures shelf life and avoids degradation, aligning with pharmaceutical industry best practices for impurity management.