Tenofovir alafenamide hemifumarate

Basic Information

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CAS Number

1392275-56-7

Molecular Formula

C46H62N12O14P2

Molecular Weight

1069.02 g/mol

EINECS

805-448-8

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

No data available

Boiling Point

No data available

Density

No data available

Flash Point

No data available

Vapor Pressure

No data available

SMILES

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CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc3ccccc3.CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc3ccccc3.OC(=O)/C=C/C(=O)O

InChI

InChI=1S/2C21H29N6O5P.C4H4O4/c2*1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27;5-3(6)1-2-4(7)8/h2*5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*15-,16+,33+;/m11./s1

InChIKey

SVUJNSGGPUCLQZ-FQQAACOVSA-N

LogP

5.657600000000005

Topological Polar Surface Area

361.56 Å²

Hydrogen Bond Donor/Acceptor

8 / 26

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)
N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1)
GS-7340 (hemifumarate)
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
Tenofovir levamide amine fumarate
GS7340(Tenofovir Alafenamide Fumarate)
(Tenofovir alafenamide : fumarate = 2:1)
Anti-HIV
GS7340（Tenofovir Alafenamide Fumarate）
GS-7340 Hemifumarate
Tenofovir alafenamide fumarate, 2:1
L-Alanine,N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-,1-methylethyl ester,(2E)-2-butenedioate (2:1)
GS-7340-03
1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate,(2E)-2-butenedioate
(E)-but-2-enedioic acid,propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate
(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1)
Tenofovir Alafenamide Fumarate
Tenofovir alafenamide fumarate(2:1)
GS7340 hemifumarate
Tenofovir alafenamide hemifumarate
GS 7340-03

MDL Number

MFCD30534429

EC Number

805-448-8

FAQ

What is Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7)?

Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7) is an antiretroviral medication used to treat HIV infections. It is a prodrug form of tenofovir, designed to improve bioavailability and reduce systemic toxicity. The compound has a molecular formula of C14H21N6O15P and is characterized by its stability in solid form, solubility in water, and role as a nucleotide reverse transcriptase inhibitor (NRTI) in pharmaceutical applications.

What are the main uses of Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7)?

Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7) is primarily used in the pharmaceutical industry for HIV treatment, as part of combination antiretroviral therapy (ART). It is also employed in research for studying antiviral mechanisms and drug development. Its high solubility and improved pharmacokinetic profile make it a key compound in combating HIV and related viral infections.

Is Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7) safe?

Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7) is considered safe when used as directed in medical treatments. It has low toxicity compared to other NRTIs and is generally well-tolerated. However, handling precautions include avoiding direct contact with skin or eyes, using protective gloves, and following standard lab safety protocols. Safety standards ensure its proper use in pharmaceutical applications and compliance with regulatory guidelines.

How should Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7) be stored?

Tenofovir alafenamide hemifumarate (CAS: 1392275-56-7) should be stored in a cool, dry place at 2-8°C, protected from light. It requires airtight containers to maintain stability and prevent moisture exposure. Proper storage ensures optimal shelf life and preserves its pharmaceutical efficacy, as recommended by manufacturers and safety standards.