(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate

Basic Information

View in Editor

CAS Number

1391463-17-4

Molecular Formula

C14H18FNO6

Molecular Weight

315.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

View in Editor

C1CC(NC1)C2=CC(=CC=C2)F.C(C(C(=O)O)O)(C(=O)O)O

InChI

InChI=1S/C10H12FN.C4H6O6/c11-9-4-1-3-8(7-9)10-5-2-6-12-10;5-1(3(7)8)2(6)4(9)10/h1,3-4,7,10,12H,2,5-6H2;1-2,5-6H,(H,7,8)(H,9,10)/t10-;1-,2-/m11/s1

InChIKey

LPQAIJHTOIUGNX-PRCBPEIBSA-N

LogP

0.1276

Topological Polar Surface Area

127.09 Å²

Hydrogen Bond Donor/Acceptor

5 / 7

Complexity

283

Synonyms & References

English

(R)-2-(3-Fluorophenyl)pyrrolidine L-Tartrate
(R)-2-(3-fluorophenyl)pyrrolidine (2R,3R)-2,3-dihydroxysuccinate
(R)-2-(3-Fluorophenyl)pyrrolidineL-Tartrate
C10H12FN.C4H6O6
4802AJ
AB0064925
(R)-2-(3-Fluorophenyl)pyrrolidinyl L-Bammat
(2R,3R)-2,3-Dihydroxybutanedioic acid--(2R)-2-(3-fluorophenyl)pyrrolidine (1/1)
(2R)-2-(3-FLUOROPHENYL)PYRROLIDINE; L(+)-TARTARIC ACID
DB-310257
(2R,3R)-2,3-dihydroxybutanedioic acid;(2R)-2-(3-fluorophenyl)pyrrolidine
1391463-17-4
AKOS024438530
(R)-2-(3-FLUOROPHENYL)PYRROLIDINE L-TARTRATE
MFCD16883079
AS-32550
CS-0060400
A886133
DTXSID80719860
C14H18FNO6

MDL Number

MFCD16883079

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate (CAS: 1391463-17-4)?

(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate is a crystalline compound with a molecular weight of approximately 302.23 g/mol. It has a melting point of about 160-162°C and is sparingly soluble in water. The compound is known for its moderate reactivity, particularly towards nucleophiles. It can form complexes with various metals and is often used in pharmaceutical applications due to its structural stability.

How is (R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate (CAS: 1391463-17-4) typically synthesized?

(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate is commonly synthesized via a multistep process involving the protection of the primary amine, fluorination of the aromatic ring, and subsequent formation of the pyrrolidine ring. The synthesis often employs catalytic hydrogenation and chiral resolution techniques to achieve high enantiomeric purity. Typical yield ranges from 70-85%.

What industries use (R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate (CAS: 1391463-17-4)?

(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate finds application in the pharmaceutical and fine chemical industries. It is used as an intermediate in the synthesis of various drugs, particularly in prodrugs and chiral pharmaceuticals. Additionally, it is utilized in the production of chiral catalysts for asymmetric synthesis and as a building block for chiral polymers in the polymer industry.

What precautions should be taken when handling (R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate (CAS: 1391463-17-4)?

When handling (R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a closed container away from direct sunlight and heat sources. Fume hoods should be used during handling to minimize inhalation exposure. In case of a spill, immediately clean up with appropriate absorbent material and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.