(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate(CAS: 1391463-17-4)

(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate is a crystalline compound with a molecular weight of approximately 302.23 g/mol. It has a melting point of about 160-162°C and is sparingly soluble in water. The compound is known for its moderate reactivity, particularly towards nucleophiles. It can form complexes with various metals and is often used in pharmaceutical applications due to its structural stability.

(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate is commonly synthesized via a multistep process involving the protection of the primary amine, fluorination of the aromatic ring, and subsequent formation of the pyrrolidine ring. The synthesis often employs catalytic hydrogenation and chiral resolution techniques to achieve high enantiomeric purity. Typical yield ranges from 70-85%.

(R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate finds application in the pharmaceutical and fine chemical industries. It is used as an intermediate in the synthesis of various drugs, particularly in prodrugs and chiral pharmaceuticals. Additionally, it is utilized in the production of chiral catalysts for asymmetric synthesis and as a building block for chiral polymers in the polymer industry.

When handling (R)-2-(3-Fluorophenyl)pyrrolidine L-tartrate, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a closed container away from direct sunlight and heat sources. Fume hoods should be used during handling to minimize inhalation exposure. In case of a spill, immediately clean up with appropriate absorbent material and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.