4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol | CAS No. 1391052-04-2

4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol

Basic Information

CAS Number

1391052-04-2

Molecular Formula

C34H47NO7

Molecular Weight

581.75 g/mol

AD

Basic Physical Properties

C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)OCC(C3=CC(=C(C=C3)O)CO)O)CO)O

InChI

InChI=1S/C34H47NO7/c36-23-29-20-28(13-15-31(29)38)33(40)25-42-34-16-14-27(21-30(34)24-37)32(39)22-35-17-7-1-2-8-18-41-19-9-6-12-26-10-4-3-5-11-26/h3-5,10-11,13-16,20-21,32-33,35-40H,1-2,6-9,12,17-19,22-25H2

InChIKey

ZHRQOSRFSAZSAM-UHFFFAOYSA-N

LogP

4.712100000000008

Topological Polar Surface Area

131.64000000000001 Ų

Hydrogen Bond Donor/Acceptor

6 / 8

Complexity

664

Synonyms & References

English

  • SalMeterol EP IMpurity D
  • 1-[4-[2-Hydroxy-2-[4-hydroxy-3-(hydroxyMethyl)phenyl]ethoxy]-3-(hydroxyMethyl)phenyl]-2-[[6-(3-phenylbutoxy)hexyl]aMino]ethanol
  • 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxyMethyl)phenyl]ethyl] SalMeterol
  • 4-[1-hydroxy-2-[2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenoxy]ethyl]-2-(hydroxymethyl)phenol
  • starbld0021285
  • 1391052-04-2
  • SCHEMBL14030622
  • 1-(4-(2-Hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethoxy)-3-(hydroxymethyl)phenyl)-2-((6-(3-phenylbutoxy)hexyl)amino)ethanoll
  • Q27258712
  • Salmeterol EP Impurity D
  • 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol
  • Salmeterol xinafoate specified impurity D [EP]
  • 4-(1-Hydroxy-2-(4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenoxy)ethyl)-2-(hydroxymethyl)phenol
  • 1-[4-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethoxy]-3-(hydroxy-methyl)phenyl]-2-[[6-(3-phenylbutoxy)hexyl]-amino]ethanol; Salmeterol Xinafoate Imp. D (EP)
  • UNII-446ID5759Z
  • SALMETEROL XINAFOATE IMPURITY D [EP IMPURITY]
  • 4-O-(2-Hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethyl) salmeterol
  • 446ID5759Z
  • 4-(1-hydroxy-2-(4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenoxy)ethyl)-2-(hydroxymethyl)phenol

FAQ

What are the physical and chemical properties of 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol (CAS: 1391052-04-2)?

4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol is a crystalline compound with a molecular weight of approximately 545.4 g/mol. It is sparingly soluble in water and methanol. The compound is relatively stable under normal conditions but exhibits slight reactivity towards strong alkalis. It is important to handle it under mild conditions to avoid degradation.

How is 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol (CAS: 1391052-04-2) typically synthesized?

The synthesis of 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol is typically achieved through multi-step organic reactions including a condensation reaction and a series of protecting group manipulations. The reaction proceeds with high selectivity and good yield under mild conditions, using standard organic solvents and mild bases.

What industries use 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol (CAS: 1391052-04-2)?

4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol is primarily used in the pharmaceutical industry for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It is also of interest in the polymer industry for its potential use as a monomer or additive.

What precautions should be taken when handling 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol (CAS: 1391052-04-2)?

When handling 4-O-[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl] Salmeterol, it is important to use personal protective equipment (PPE) such as gloves and safety goggles. It should be stored in a cool, dry place away from direct sunlight. In case of spill, it is recommended to use appropriate absorbents and follow the safety data sheet (SDS) for further instructions.

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