N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide | CAS No. 13880-05-2

Q: What are the physical and chemical properties of N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2)?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) is a colorless to light yellow crystalline solid with a boiling point of approximately 220°C and a molecular weight of 240.21 g/mol. It is soluble in water and organic solvents. Chemically, it is reactive and can undergo various polymerization and condensation reactions.

Q: How is N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) typically synthesized?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide is typically synthesized through the condensation of acryloyl chloride with 1,3-propanediol. The reaction is catalyzed by an acid or base and proceeds with high selectivity and yield. Common solvents include dichloromethane or acetonitrile.

Q: What industries use N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2)?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) is used in the pharmaceutical industry for the synthesis of macromolecular drugs, in the polymer industry for the production of specialized polymers, and in the sensor industry for the development of biosensors. It is also used in semiconductor manufacturing as a precursor in the fabrication of thin films.

Q: What precautions should be taken when handling N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2)?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) should be handled in a well-ventilated area and with personal protective equipment (PPE), such as gloves, goggles, and a lab coat. It should be stored in a fume hood to minimize exposure. Spills should be handled with appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed handling and disposal instructions.

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide

Basic Information

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CAS Number

13880-05-2

Molecular Formula

C7H13NO4

Molecular Weight

175.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Physical Properties

Melting Point

136-141 °C

Boiling Point

510.8 ℃ at 760 mmHg

Density

1.3±0.1 g/cm3

Water Solubility

Soluble in water.

Flash Point

262.7±30.1 °C

Refractive Index

1.528

Vapor Pressure

0.0±3.0 mmHg at 25°C

SMILES

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C=CC(=O)NC(CO)(CO)CO

InChI

InChI=1S/C7H13NO4/c1-2-6(12)8-7(3-9,4-10)5-11/h2,9-11H,1,3-5H2,(H,8,12)

InChIKey

MVBJSQCJPSRKSW-UHFFFAOYSA-N

LogP

-1.9956999999999994

Topological Polar Surface Area

89.78999999999999 Å²

Hydrogen Bond Donor/Acceptor

4 / 5

Complexity

157

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Light Sensitive & Hygroscopic

Synonyms & References

English

TRIS-acrylamide
N-Acryloyltris(hydroxymethyl)aminomethane
NS00024490
DTXSID60160790
N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]prop-2-enamide
UNII-R8VGY8CVF2
N-Acryloyl-tris(hydroxymethyl)aminomethane
AKOS015900619
N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
STR02781
MFCD00081045
N-[Tris(hydroxymethyl)methyl]acrylamide, contains <=7% KCl, 93%
EINECS 237-645-4
FT-0636974
N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)acrylamide
C93420
2-Propenamide, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
R8VGY8CVF2
J-007179
N-[Tris(hydroxymethyl)methyl]acrylamide
N-(2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL)-2-PROPENAMIDE
tris(hydroxymethyl)acrylaminomethane
SCHEMBL105869
n-[tris(hydroxymethyl)methyl]-acrylamide
30347-69-4
2-Propenamide, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-
CS-0158040
13880-05-2
N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
NAT,TRIS-acrylamide
NAT

MDL Number

MFCD00081045

Customs Code

2924199090

FAQ

What are the physical and chemical properties of N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2)?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) is a colorless to light yellow crystalline solid with a boiling point of approximately 220°C and a molecular weight of 240.21 g/mol. It is soluble in water and organic solvents. Chemically, it is reactive and can undergo various polymerization and condensation reactions.

How is N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) typically synthesized?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide is typically synthesized through the condensation of acryloyl chloride with 1,3-propanediol. The reaction is catalyzed by an acid or base and proceeds with high selectivity and yield. Common solvents include dichloromethane or acetonitrile.

What industries use N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2)?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) is used in the pharmaceutical industry for the synthesis of macromolecular drugs, in the polymer industry for the production of specialized polymers, and in the sensor industry for the development of biosensors. It is also used in semiconductor manufacturing as a precursor in the fabrication of thin films.

What precautions should be taken when handling N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2)?

N-[1,3-Dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide (CAS: 13880-05-2) should be handled in a well-ventilated area and with personal protective equipment (PPE), such as gloves, goggles, and a lab coat. It should be stored in a fume hood to minimize exposure. Spills should be handled with appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed handling and disposal instructions.