Irbesartan | CAS No. 138402-11-6

Irbesartan

Basic Information

View in Editor

CAS Number

138402-11-6

Molecular Formula

C25H28N6O

Molecular Weight

428.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

185.0 to 190.0 deg-C

Boiling Point

648.6°C at 760 mmHg

Density

1.3

Flash Point

346 °C

Solubility

DMSO: >25mg/mL

Refractive Index

1.689

SMILES

View in Editor

CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5[nH]nnn5

InChI

InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

InChIKey

YOSHYTLCDANDAN-UHFFFAOYSA-N

LogP

4.777400000000004

Topological Polar Surface Area

87.13000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

682

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
Irbesartan (GMP)
3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE
BMS-186295
AVAPRO
APROVEL
SR-47436
Irbesartan
3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)-methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
2-Butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]1,3-diaza-spiro[4.4]non-1-en-4-one
2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Karvea
BMS 186295
Irbesartan [USAN:INN]
SR 47436
8-butyl-7-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-7,9-diazaspiro[4.4]non-8-en-6-one
C25H28N6O
YOSHYTLCDANDAN-UHFFFAOYSA-N
J0E2756Z7N
2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
Avapro
3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one
3-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

MDL Number

MFCD00864464

Customs Code

2933990090

FAQ

What is Irbesartan (CAS: 138402-11-6)?

Irbesartan is an angiotensin II receptor blocker (ARB) used primarily in the treatment of hypertension. Its chemical formula is C15H16N4O3S, and it is a white to off-white crystalline solid with good solubility in certain solvents. It is commonly used in pharmaceutical formulations and is known for its selective antagonism of the AT1 receptor, which helps reduce blood pressure.

What are the main uses of Irbesartan (CAS: 138402-11-6)?

Irbesartan is mainly used as a medication for managing high blood pressure (hypertension). It is also prescribed for patients with diabetes to protect kidney function. In research, it is utilized to study the effects of angiotensin II receptor blockade on cardiovascular health. Additionally, it is used in combination therapies for more effective blood pressure control.

Is Irbesartan (CAS: 138402-11-6) safe?

Irbesartan is generally considered safe when used as directed. It has a favorable safety profile with minimal side effects, although precautions should be taken in patients with renal impairment or those on potassium-sparing diuretics. Proper handling and adherence to safety guidelines are essential to ensure its safe use in both medical and research settings.

How should Irbesartan (CAS: 138402-11-6) be stored?

Irbesartan should be stored in a cool, dry place away from direct light. It is stable at room temperature (15-25°C) and should be kept in a sealed container to prevent moisture absorption. Proper storage conditions help maintain its potency and effectiveness over time.