Tropifexor | CAS No. 1383816-29-2

Tropifexor

Basic Information

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CAS Number

1383816-29-2

Molecular Formula

C29H25F4N3O5S

Molecular Weight

603.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Solubility

Insuluble (2.0E-6 g/L) (25 ºC),

SMILES

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OC(=O)c1cc(F)c2c(c1)sc(n2)N1[C@@H]2CC[C@H]1C[C@H](C2)OCc1c(onc1c1ccccc1OC(F)(F)F)C1CC1

InChI

InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+

InChIKey

VYLOOGHLKSNNEK-PIIMJCKOSA-N

LogP

7.2812000000000054

Topological Polar Surface Area

97.92 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

979

Synonyms & References

English

2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid
LJN-452
Tropifexor
2-[(3-endo)-3-[[5-Cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-6-benzothiazolecarboxylic acid
LJN 452
rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid
LJN452
Tropifexor (LJN452)
NMZ08KM76Z
Tropifexor (USAN)
Tropifexor [USAN]
2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
Tropifexor [INN]
LJN452; Tropifexor
Tropifexor [USAN:INN]
GTPL9725
rel-2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)ph

MDL Number

MFCD31619256

FAQ

What is Tropifexor (CAS: 1383816-29-2)?

Tropifexor is a potent and selective inhibitor of the farnesoid X receptor (FXR), a key regulator of bile acid homeostasis and glucose metabolism. It is used in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH).

What are the main uses of Tropifexor (CAS: 1383816-29-2)?

Tropifexor is primarily used in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH). It is also under investigation for potential applications in other metabolic disorders.

Is Tropifexor (CAS: 1383816-29-2) safe?

Tropifexor is generally considered safe for use in clinical trials, but it may cause side effects such as nausea, headache, and hyperglycemia. Careful monitoring and adherence to safety guidelines are recommended during its administration.

How should Tropifexor (CAS: 1383816-29-2) be stored?

Tropifexor should be stored at room temperature (15-30°C) and protected from light. It should be kept in a tightly closed container and away from moisture and heat sources.