Duloxetine, HCl

Basic Information

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CAS Number

136434-34-9

Molecular Formula

C18H20ClNOS

Molecular Weight

333.9 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

162.0 to 166.0 deg-C

Solubility

H2O: soluble5mg/mL (clear solution, warmed)

Specific Rotation

+116.0° - +125.0° (c=1, MeOH)

SMILES

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CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl

InChI

InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1

InChIKey

BFFSMCNJSOPUAY-LMOVPXPDSA-N

LogP

5.82380

pKa

pKa in DMF-water (66:34): 9.6(at 25℃)

Complexity

312

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

MLS006010054
(S)-duloxetine hydrochloride
Cymbalta
D01179
Duloxetine Hydrochloride20 mg
N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine hydrochloride
Duloxetine hydrochloride [USAN]
DuloxetineDelayed-Release
Chlorhydrate de duloxetine
NCGC00164559-03
Duloxetine hydrochloride, European Pharmacopoeia (EP) Reference Standard
LY248686 HCl
LY-264453
MFCD06407958
AMY12420
2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, hydrochloride, (gammaS)-
Yentreve (TN)
Duloxetine HCl
2-THIOPHENEPROPANAMINE, N-METHYL-.GAMMA.-(1-NAPHTHALENYLOXY)-, HYDROCHLORIDE, (S)-
Duloxetina cloridrato
Duloxetine.HCL
Duloxetine Hydrochloride60 mg
Tox21_112188_1
Duloxetine Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
DULOXETINE HYDROCHLORIDE [WHO-DD]
DULOXETINE HYDROCHLORIDE [USP-RS]
Duloxetine Hydrochloride 1.0 mg/ml in Methanol (as free base)
DULOXETINE HYDROCHLORIDE (USP MONOGRAPH)
NSC759112
CHEBI:31526
CHEMBL1200328

MDL Number

MFCD06407958

Customs Code

2934999090

FAQ

What is Duloxetine, HCl (CAS: 136434-34-9)?

Duloxetine, HCl (CAS: 136434-34-9) is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used primarily in pharmaceutical applications. Its chemical formula is C15H18N2O2·HCl, and it appears as a white to off-white crystalline powder. It is soluble in water and has a molecular weight of approximately 301.78 g/mol. Duloxetine, HCl is known for its use in treating depression and anxiety disorders due to its mechanism of action on neurotransmitters.

What are the main uses of Duloxetine, HCl (CAS: 136434-34-9)?

Duloxetine, HCl (CAS: 136434-34-9) is mainly used as a medication for the treatment of major depressive disorder, generalized anxiety disorder, and diabetic neuropathy. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood and reduce pain. In addition to its pharmaceutical applications, it may be used in research for studying neurochemical pathways and in industrial settings for the production of related compounds.

Is Duloxetine, HCl (CAS: 136434-34-9) safe?

Duloxetine, HCl (CAS: 136434-34-9) is considered safe when used as prescribed, but it should be handled with care. It is generally well-tolerated, though side effects such as nausea, dizziness, and insomnia may occur. Long-term use requires monitoring for potential risks, including serotonin syndrome and liver damage. Safety standards ensure proper storage and usage conditions to maintain its efficacy and minimize adverse effects.

How should Duloxetine, HCl (CAS: 136434-34-9) be stored?

Duloxetine, HCl (CAS: 136434-34-9) should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 30°C (59°F to 86°F) and should be protected from moisture. Proper storage in a sealed container helps maintain its stability and potency. Always follow recommended storage guidelines to ensure safety and effectiveness.