Lobaplatin | CAS No. 135558-11-1

Lobaplatin

Basic Information

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CAS Number

135558-11-1

Molecular Formula

C9H18N2O3Pt

Molecular Weight

397.33 g/mol

EINECS

604-604-1

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

220° (dec)

Water Solubility

Water: ≥ 50 mg/mL (125.84 mM; DMSO can inactivate Lobaplatin's activity)

SMILES

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O=C1[O-][Pt]2([O-]C1C)[NH2+]CC1C(C[NH2+]2)CC1

LogP

0.53800

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 i.p. in mice: 46 mg/kg (Voegeli)

Synonyms & References

English

d19466
Lobaplatin (D-19466)
Platinum, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-.kappa.N,.kappa.N'][(2S)-2-(hydroxy-.kappa.O)propanoato(2-)-.kappa.O]-, (SP-4-3)- (9CI) (CA INDEX NAME)
Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)- (9CI)
Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-
Platinum, (1,2-cyclobutanedimethanamine-N,N')[2-hydroxypropanoato(2-)-O1,O2]-, [SP-4-3-(S),(trans)]-[D-19466
cell cycle,Apoptosis,Caspase,Lobaplatin,Bax,esophageal squamous cell carcinoma,Inhibitor,D19466,D 19466,inhibit,Bcl-2 Family,diastereometric mixture of platinum(II) complexe
Platinum,[rel-(1R,2R)-1,2-cyclobutanedimethanamine-kN,kN'][(2S)-2-(hydroxy-kO)propanoato(2-)-k...
lobaplatin
Lobaplatin

MDL Number

MFCD00866545

EC Number

604-604-1

FAQ

What regulatory guidelines apply to Lobaplatin (CAS: 135558-11-1)?

Lobaplatin (CAS: 135558-11-1) is regulated under the Globally Harmonized System (GHS) for classification and labeling of chemicals, and falls under the European Union's Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. Additionally, the U.S. Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) have specific requirements for the handling and disposal of pharmaceutical compounds in the U.S.

Are there alternatives to Lobaplatin (CAS: 135558-11-1) in synthesis?

There are several alternatives to Lobaplatin (CAS: 135558-11-1) that can be used in synthesis, including other platinum-based antitumor agents such as cisplatin and carboplatin. These alternatives may vary in efficacy, toxicity, and synthesis complexity, but can serve as viable substitutes in specific chemical reactions.

What is the market or research trend for Lobaplatin (CAS: 135558-11-1)?

The market for Lobaplatin (CAS: 135558-11-1) is growing due to its effectiveness in treating certain types of cancer. Research trends are focusing on its mechanism of action, potential side effects, and the development of more targeted therapies. Additionally, there is increasing interest in the optimization of its synthesis and delivery methods for improved therapeutic outcomes.

How should waste containing Lobaplatin (CAS: 135558-11-1) be handled?

Waste containing Lobaplatin (CAS: 135558-11-1) should be collected in appropriate containers and handled under proper personal protective equipment. The waste should then be disposed of using professional hazardous waste disposal services. Environmental protection measures include minimizing exposure, proper labeling, and following local regulations on hazardous waste management.