(2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid

Basic Information

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CAS Number

135042-12-5

Molecular Formula

C10H17NO5

Molecular Weight

231.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

146-151 °C

Boiling Point

390.9°Cat760mmHg

Flash Point

190.2°C

Refractive Index

1.531

Specific Rotation

+48～+52°(c=0.67,MeOH,24℃)

SMILES

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CC(C)(C)OC(=O)N1CC(CC1C(=O)O)O

InChI

InChI=1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m1/s1

InChIKey

BENKAPCDIOILGV-RNFRBKRXSA-N

LogP

0.4412999999999998

Topological Polar Surface Area

87.07000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

296

Safety Information

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GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

N-Boc-cs-4-hydroxy-d-prolne
(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-D-proline
1218998-83-4
(2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
MFCD02094407
cis-4-hydroxy-n-tert-butoxycarbonyl-d-proline
N-Boc-cis-4-hydroxy-D-proline, 97%
(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
N-T-BOC-CIS-4-HYDROXY-D-PROLINE
cis-N-boc-4-hydroxy-D-proline
BENKAPCDIOILGV-RNFRBKRXSA-N
AC-24044
I467853HPL
Rel-(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
(2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid
N-Boc-cis-4-Hydroxy-D-proline
AS-19532
Z1250093185
cis-Boc-4-hydroxy-D-proline
HY-W002887
(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid
(2R,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
(2R,4R)-1-tert-butoxycarbonyl-4-hydroxy-pyrrolidine-2-carboxylic acid
N-Boc-4-hydroxy-D-proline, (4R)-(+)-
EN300-158256
N-Boc-4-hydroxy-D-proline, cis-
A2881
(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylicacid
AM20080250
(2R,4R)4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
Boc-D-cis-Hyp-OH

MDL Number

MFCD02094407

Customs Code

2933990090

FAQ

What regulatory guidelines apply to (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5)?

The compound (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5) falls under the scope of GHS classification for chemical hazards. In terms of regulatory requirements, it must comply with REACH regulations in the European Union, as well as FDA and EPA guidelines in the USA. Additionally, it should adhere to local and national safety and environmental regulations.

Are there alternatives to (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5) in synthesis?

In the synthesis of (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5), there are several alternatives such as using related amino acids or their derivatives. Common alternative reagents include 2-aminopyrrolidine and its protected forms. These alternatives can offer similar functionalities and can be used depending on the specific synthesis requirements and availability.

What is the market or research trend for (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5)?

The research trend for (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5) is focused on its applications in pharmaceuticals and materials science. There is an increasing demand for this compound due to its unique structural properties and its use as a building block in organic synthesis. The market trend indicates a growing interest in developing new derivatives and understanding their biological activities.

How should waste containing (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5) be handled?

Waste containing (2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (CAS: 135042-12-5) should be collected and disposed of in accordance with local and national regulations. The waste should be neutralized and rendered non-hazardous before disposal. Incineration or professional waste disposal services are recommended to ensure safety and compliance. Proper protective measures should be taken during handling to prevent environmental contamination.