Amyloid beta-Protein (Human, 1-43)

Basic Information

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CAS Number

134500-80-4

Molecular Formula

C86H150N22O27S

Molecular Weight

1956.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Solubility

Soluble in DMSO

SMILES

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NCCCCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)C(O)C)C)C(CC)C)C(C)C)C(C)C)C(C)C)CCSC)CC(C)C)C(CC)C)C(CC)C)C)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(C(C)C)NC(=O)CCC(=O)O)CO)CC(=O)N

InChI

InChI=1S/C86H150N22O27S/c1-21-45(14)68(106-85(133)70(47(16)23-3)105-72(120)48(17)94-59(114)36-90-74(122)51(26-24-25-30-87)98-77(125)54(33-56(88)111)100-78(126)55(39-109)97-61(116)38-92-79(127)64(41(6)7)101-57(112)27-28-63(118)119)81(129)93-37-60(115)96-53(32-40(4)5)76(124)99-52(29-31-136-20)75(123)103-65(42(8)9)80(128)91-34-58(113)89-35-62(117)102-66(43(10)11)82(130)104-67(44(12)13)83(131)107-69(46(15)22-2)84(132)95-49(18)73(121)108-71(50(19)110)86(134)135/h40-55,64-71,109-110H,21-39,87H2,1-20H3,(H2,88,111)(H,89,113)(H,90,122)(H,91,128)(H,92,127)(H,93,129)(H,94,114)(H,95,132)(H,96,115)(H,97,116)(H,98,125)(H,99,124)(H,100,126)(H,101,112)(H,102,117)(H,103,123)(H,104,130)(H,105,120)(H,106,133)(H,107,131)(H,108,121)(H,118,119)(H,134,135)

InChIKey

LBJNSYPWMXQDNQ-UHFFFAOYSA-N

LogP

-7.232399999999924

Topological Polar Surface Area

766.17 Å²

Hydrogen Bond Donor/Acceptor

28 / 49

Complexity

11300

Synonyms & References

English

A-BETA (1-43)
AMYLOID BETA-PROTEIN (1-43)
AMYLOID BETA-PEPTIDE (1-43) (HUMAN)
AMYLOID BETA-PROTEIN FRAGMENT 1-43
amyloid B-protein fragment 1-43
Amyloidb-Peptide(1-43)(human)
amyloid β-protein fragment 1-43
BETA-AMYLOID (1-43)
L-Threonine, L-a-aspartyl-L-alanyl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-a-glutamyl-L-a-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanyl-
Amyloid β -Protein (1- 43)
Amyloid beta-Protein (Human, 1-43)
AMYLOID Β-PEPTIDE (1-43) (HUMAN)
L-Threonine, L-a-aspartyl-L-alanyl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-a-aspart...
L-Threonine, L-a-aspartyl-L-alanyl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-
L-Threonine, L-a-aspartyl-L-alanyl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valy
Amyloid .beta.-Protein (1-43)
Beta-Amyloid (1-43)
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr-OH
CID 131954553
Amyloid
Amyloid beta-Protein (1-43)

MDL Number

MFCD00240623

FAQ

What is Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4)?

Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4) is a synthetic peptide corresponding to the first 43 amino acids of the amyloid beta protein derived from the human brain. It is used in research to model neurodegenerative diseases such as Alzheimer's disease.

What are the main uses of Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4)?

Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4) is primarily used in pharmaceutical and biomedical research for studying Alzheimer's disease and other neurodegenerative conditions. It can also be used as a substrate in assays to evaluate the activity of proteases involved in amyloid formation.

Is Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4) safe?

Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4) is generally considered safe when handled according to standard laboratory safety protocols. However, it should be used in a fume hood and proper personal protective equipment (PPE) should be worn to avoid inhalation and direct contact with skin and eyes.

How should Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4) be stored?

Amyloid beta-Protein (Human, 1-43) (CAS: 134500-80-4) should be stored in a tightly sealed vial at -20°C or below to prevent degradation. It should be protected from light and kept in a cool, dry place away from direct sunlight and heat sources.