Dicloxacillin Sodium hydrate

Basic Information

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CAS Number

13412-64-1

Molecular Formula

C19H18Cl2N3NaO6S

Molecular Weight

510.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

222-225°C

Boiling Point

692.4°Cat760mmHg

Density

g/cm3

Water Solubility

Soluble in water

Flash Point

372.5°C

Solubility

H2O: soluble50mg/mL

Specific Rotation

D20 +127.2° (water)

SMILES

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CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]

InChI

InChI=1S/C19H17Cl2N3O5S.Na.H2O/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24;;/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

InChIKey

SIGZQNJITOWQEF-VICXVTCVSA-M

LogP

2.13190

Complexity

752

Safety Information

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Toxicity

LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; >5 orally (Gloxhuber)

Synonyms & References

English

DICLOXACILLIN SODIUM [USP IMPURITY]
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S-(2alpha,5alpha,6beta))-
Ciclex
sodium (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
Novapen
NCGC00180956-01
DICLOXACILLIN SODIUM [ORANGE BOOK]
DICLOXACILLIN SODIUM [VANDF]
P 1011
DICLOXACILLINUM NATRICUM [WHO-IP LATIN]
SCHEMBL41515
Dicloxacillin sodium salt hydrate
Tox21_113495
DICLOXACILLIN SODIUM [USP MONOGRAPH]
Digloxilline
DICLOXACILLIN SODIUM [USP-RS]
NCGC00178782-02
Dicloxacillin sodium salt monohydrate
3116-76-5 (non-salt)
CHEBI:52019
Dicloxacillin sodium, United States Pharmacopeia (USP) Reference Standard
DICLOXACILLIN SODIUM MONOHYDRATE
Constaphyl
AKOS015962897
DICLOXACILLIN SODIUM [USAN]
CCG-220450
4HZT2V9KX0
CCG-269777
Monosodium (2S,5R,6R)-6-[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0]heptane-2-carboxylate monohydrate
BDBM50005106
AC-18976

MDL Number

MFCD00167147

Customs Code

2941109900

FAQ

What regulatory guidelines apply to dicloxacillin sodium hydrate (CAS: 13412-64-1)?

Dicloxacillin sodium hydrate (CAS: 13412-64-1) must comply with GHS classification for health hazards, REACH regulations, and FDA/EPA guidelines for pharmaceutical and medicinal uses. It is classified as a Schedule V controlled substance and requires proper labeling and storage for safety and efficacy.

Are there alternatives to dicloxacillin sodium hydrate (CAS: 13412-64-1) in synthesis?

Alternatives to dicloxacillin sodium hydrate include other penicillin derivatives and cephalosporins. Common substitutes in synthesis might include amoxicillin or cephalexin, which offer similar antibacterial properties. Isomers and analogs like dicloxacillin potassium can also be considered in certain formulations.

What is the market or research trend for dicloxacillin sodium hydrate (CAS: 13412-64-1)?

The market trend for dicloxacillin sodium hydrate shows a steady demand due to its effectiveness against beta-lactamase-producing Staphylococcus aureus. Research is focusing on the development of new antibiotics and resistance management strategies to counter growing bacterial resistance. Price trends are stable, with demand correlating with the prevalence of resistant infections.

How should waste containing dicloxacillin sodium hydrate (CAS: 13412-64-1) be handled?

Waste containing dicloxacillin sodium hydrate should be collected in appropriate containers, ensuring it is labeled as a hazardous material. It should be handled according to local regulations and guidelines, typically through incineration or professional waste disposal services. Environmental protection measures include proper containment to prevent release into the environment.