N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine | CAS No. 132327-80-1

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine

Basic Information

CAS Number

132327-80-1

Molecular Formula

C39H34N2O5

Molecular Weight

610.71 g/mol

AD

Basic Physical Properties

Melting Point

165-172 ºC

Density

1.2560

Specific Rotation

-14.0±1.5°, (c=1% in DMF)

C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)NC(=O)CCC(C(=O)O)NC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

InChI

InChI=1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1

InChIKey

WDGICUODAOGOMO-DHUJRADRSA-N

LogP

6.866800000000007

Topological Polar Surface Area

104.73 Ų

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

946

Safety Information

View Safety Information

GHS Hazard Pictograms

H317H317
H413

Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin
H413 May cause long lasting harmful effects to aquatic life
Hazardous to the aquatic environment, long-term hazard

Sensitiveness

Moisture Sensitive

Synonyms & References

English

  • SCHEMBL120503
  • AMY22600
  • EN300-96403
  • (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-oxo-5-(tritylamino)pentanoic acid
  • (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid
  • FD21528
  • WDGICUODAOGOMO-DHUJRADRSA-N
  • HY-W013081
  • N-Fmoc-N5-trityl-L-Glutamine
  • J-300128
  • Nalpha-Fmoc-Ndelta-trityl-L-glutamine;N-Fmoc-N5-trityl-L-Glutamine
  • N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-L-glutamine
  • MFCD00077056
  • AS-12973
  • Fmoc-Gln(Trt)-OH
  • N2-Fmoc-N5-trityl-L-glutamine
  • N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N5-trityl-L-glutamine
  • CS-W013797
  • DTXSID70448258
  • AKOS015895396
  • AKOS015924207
  • Fmoc-L-Gln(Trt)-OH
  • L-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-
  • M03356
  • Nalpha-Fmoc-Ndelta-trityl-L-glutamine
  • N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-gamma-trityl-L-glutamine
  • (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-(tritylamino)pentanoic acid
  • N-Fmoc-N'-trityl-L-glutamine
  • Fmoc-Gln(Trt)-OH, >=98.0% (HPLC)
  • (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-[tri(phenyl)methylamino]pentanoic acid
  • (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid

MDL Number

MFCD00077056

FAQ

What is N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1)?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1) is a protected amino acid derivative commonly used in peptide synthesis. Its chemical formula is C27H29N3O4, and it features a fluorenylmethoxy carbonyl (Fmoc) group attached to the glutamine molecule. This compound is stable in organic solvents and has limited solubility in water, making it suitable for specialized chemical applications.

What are the main uses of N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1)?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1) is primarily used in pharmaceutical research as a building block for drug development. It serves as a protected amino acid in peptide synthesis and is also employed in biochemical studies for analyzing amino acid metabolism. Additionally, it functions as an intermediate in organic chemistry for creating complex molecules.

Is N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1) safe?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1) is generally safe when handled properly. It is not classified as toxic, but standard safety precautions should be followed, such as wearing gloves and goggles to avoid skin or eye contact. Ensure proper ventilation and follow OSHA guidelines for chemical handling to maintain safety.

How should N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1) be stored?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-trityl-L-glutamine (CAS: 132327-80-1) should be stored in a tightly sealed container in a cool, dry place (below 25°C) away from light. It is stable under these conditions but should be protected from moisture and heat to prevent degradation. Store in a well-ventilated area to maintain chemical integrity.

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