N-[(3R)-3-Pyrrolidinyl]acetamide

Basic Information

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CAS Number

131900-62-4

Molecular Formula

C6H12N2O

Molecular Weight

128.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Solid

Melting Point

55.0 to 60.0 deg-C

Boiling Point

70-72 °C/40 mmHg

Flash Point

70-72°C/40mm

Refractive Index

47 ° (C=1, EtOH)

SMILES

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CC(=O)NC1CCNC1

InChI

InChI=1S/C6H12N2O/c1-5(9)8-6-2-3-7-4-6/h6-7H,2-4H2,1H3,(H,8,9)/t6-/m1/s1

InChIKey

HDCCJUCOIKLZNM-ZCFIWIBFSA-N

LogP

-0.5156000000000003

Topological Polar Surface Area

41.13 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

114

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

(3R)-(+)-3-Acetamidopyrrolidine
Acetamide, N-(3R)-3-pyrrolidinyl-
MFCD00082729
(R)-3-Acetamidopyrrolidine
(R)-N-pyrrolidin-3-ylacetamide
N-[(3R)-pyrrolidin-3-yl]acetamide
DTXSID60426803
SCHEMBL39918
(3R)-3-ACETAMIDOPYRROLIDINE
A1169
AKOS015897786
N-(3-Pyrrolidinyl)acetamide #
DS-15659
(R)-N-(pyrrolidin-3-yl)acetamide;(R)-3-ACETAMIDOPYRROLIDINE
131900-62-4
(3R)-(-)-3-Acetamidopyrrolidine
AC-6725
(R)-N-(pyrrolidin-3-yl)acetamide
CS-0048830
(R)-N-(Pyrrolidin-3-yl)acetamide
(R)-N-Pyrrolidin-3-ylacetamide
R-AAP
Acetamide,N-3-pyrrolidinyl-, (R)-
(3R)-3-Acetamidopyrrolidine
(R)-(+)-3-Acetamidopyrrolidine
(R)-3-(Acetylamino)pyrrolidine
(R)-N-(Pyrrolidin-3-yl)ethanamide
N-(3R)-3-Pyrrolidinylacetamide
(R)-3-ACETAMIDO-PYRROLIDINE
(R)-3-Acetylaminopyrrolidine
(R)-N-PYRROLIDIN-3-YL-ACETAMIDE

MDL Number

MFCD00082729

Customs Code

2933990090

FAQ

What are the physical and chemical properties of N-[(3R)-3-Pyrrolidinyl]acetamide (CAS: 131900-62-4)?

N-[(3R)-3-Pyrrolidinyl]acetamide is a white crystalline solid with a molecular weight of 148.21 g/mol. It is slightly soluble in water and has good solubility in common organic solvents like methanol and ethanol. The compound is stable under normal conditions but reacts with strong acids and bases. It is less reactive towards nucleophiles and electrophiles, making it suitable for various synthetic transformations.

How is N-[(3R)-3-Pyrrolidinyl]acetamide (CAS: 131900-62-4) typically synthesized?

N-[(3R)-3-Pyrrolidinyl]acetamide can be synthesized by the amidation of 3-(aminomethyl)pyrrolidin-3-ol with acetic anhydride in the presence of a base such as triethylamine. The reaction is selective and yields a high percentage of the desired product. The process involves mixing the pyrrolidine derivative with acetic anhydride and triethylamine, stirring under mild conditions, and then purifying the product using recrystallization or column chromatography.

What industries use N-[(3R)-3-Pyrrolidinyl]acetamide (CAS: 131900-62-4)?

N-[(3R)-3-Pyrrolidinyl]acetamide is primarily used in the pharmaceutical industry for its role as a building block in the synthesis of drugs. It is also utilized in the polymer industry for improving the properties of polymers. Additionally, it has potential applications in the sensor and semiconductor industries due to its functional groups that can be modified for specific functionalities.

What precautions should be taken when handling N-[(3R)-3-Pyrrolidinyl]acetamide (CAS: 131900-62-4)?

When handling N-[(3R)-3-Pyrrolidinyl]acetamide, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions. The compound is not particularly hazardous, but proper safety measures should always be followed.