Compound Q&A
How is N-[(3R)-3-Pyrrolidinyl]acetamide (CAS: 131900-62-4) typically synthesized?
Answer
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N-[(3R)-3-Pyrrolidinyl]acetamide can be synthesized by the amidation of 3-(aminomethyl)pyrrolidin-3-ol with acetic anhydride in the presence of a base such as triethylamine. The reaction is selective and yields a high percentage of the desired product. The process involves mixing the pyrrolidine derivative with acetic anhydride and triethylamine, stirring under mild conditions, and then purifying the product using recrystallization or column chromatography.
About
CAS No
131900-62-4
English Name
N-[(3R)-3-Pyrrolidinyl]acetamide
Molecular Formula
C6H12N2O
Molecular Weight
128.17 g/mol
SMILES
CC(=O)NC1CCNC1
InChIKey
HDCCJUCOIKLZNM-ZCFIWIBFSA-N
Last Updated: 2025-11-01 22:12
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