Trimetazidine dihydrochloride

Basic Information

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CAS Number

13171-25-0

Molecular Formula

C14H24Cl2N2O3

Molecular Weight

339.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

231-235 ºC

SMILES

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COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl

InChI

InChI=1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H

InChIKey

VYFLPFGUVGMBEP-UHFFFAOYSA-N

LogP

1.9611999999999998

Topological Polar Surface Area

42.96000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

259

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Toxicity

LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)

Synonyms & References

English

TRIMETAZIDINE HYDROCHLORIDE [MART.]
Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, dihydrochloride
Trimetajust
2,3,4-trimethoxybenzylpiperazine dihydrochloride
SCHEMBL580378
Prestwick_871
NCGC00016697-01
VYFLPFGUVGMBEP-UHFFFAOYSA-N
Trimetazidine HCl
SR-01000781912-4
TRIMETAZIDINE HYDROCHLORIDE [WHO-DD]
Vastarel F
Yosimilon
Trimetazidine for system suitability, European Pharmacopoeia (EP) Reference Standard
NSC 759317
Trimetazidine 2HCl
CAS-13171-25-0
AB05480
Kyurinett
s4543
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
F2173-1142
Q27259190
T2726
Adexor
CS-4453
48V6723Z1P
SR-01000781912-3
W-108326
Lubomail
NCGC00016697-04

MDL Number

MFCD00243086

Customs Code

2933499090

FAQ

What is Trimetazidine dihydrochloride (CAS: 13171-25-0)?

Trimetazidine dihydrochloride (CAS: 13171-25-0) is a pharmaceutical compound used primarily as a metabolic modulator. It has the chemical formula C10H12N2O2·HCl and is known for its ability to improve cellular energy efficiency by promoting the utilization of fatty acids over glucose. It is a white crystalline powder with good solubility in water and is commonly used in drug formulations for cardiovascular support.

What are the main uses of Trimetazidine dihydrochloride (CAS: 13171-25-0)?

Trimetazidine dihydrochloride (CAS: 13171-25-0) is mainly used in the treatment of angina pectoris and other cardiovascular conditions. It helps enhance myocardial oxygen efficiency and is also used in research for its potential in metabolic disorders and diabetes management. In industry, it serves as an intermediate in the synthesis of various pharmaceuticals and chemicals.

Is Trimetazidine dihydrochloride (CAS: 13171-25-0) safe?

Trimetazidine dihydrochloride (CAS: 13171-25-0) is generally considered safe when used as directed. It has a favorable safety profile in therapeutic doses, though it should be handled with care to avoid inhalation or skin contact. Proper protective measures, such as gloves and ventilation, are recommended during handling. It complies with safety standards for pharmaceutical use and is classified as low toxicity.

How should Trimetazidine dihydrochloride (CAS: 13171-25-0) be stored?

Trimetazidine dihydrochloride (CAS: 13171-25-0) should be stored in a cool, dry place away from direct light. It is stable at room temperature (15–25°C) and should be kept in airtight containers to prevent moisture absorption. Storage in a well-ventilated area is recommended to maintain its chemical integrity and ensure safety during handling.