Duocarmycin SA | CAS No. 130288-24-3

Duocarmycin SA

Basic Information

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CAS Number

130288-24-3

Molecular Formula

C25H23N3O7

Molecular Weight

477.5 g/mol

Basic Physical Properties

SMILES

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COC1=C(C(=C2C(=C1)C=C(N2)C(=O)N3CC4CC45C3=CC(=O)C6=C5C=C(N6)C(=O)OC)OC)OC

InChI

InChI=1S/C25H23N3O7/c1-32-17-6-11-5-14(26-19(11)22(34-3)21(17)33-2)23(30)28-10-12-9-25(12)13-7-15(24(31)35-4)27-20(13)16(29)8-18(25)28/h5-8,12,26-27H,9-10H2,1-4H3/t12-,25-/m1/s1

InChIKey

VQNATVDKACXKTF-XELLLNAOSA-N

LogP

2.74020

Complexity

971

Synonyms & References

English

HY-12456
130288-24-3
1609242-21-8
EX-A7932
methyl (1R,12S)-7-oxo-10-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-5,10-diazatetracyclo[7.4.0.01,12.02,6]trideca-2(6),3,8-triene-4-carboxylate
SCHEMBL61916
DTXSID30926663
CS-0011400
duocarmycin sa
duocarmycinsa
AKOS032946598
Cyclopropa(c)pyrrolo(3,2-e)indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester, (7bR)-
CHEBI:207004
Antibiotic DC113
N6-[(Allylamino]carbonothioyl]lysine (AITC-Lys)
(+)-duocarmycin SA
CHEMBL308086
Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylicacid,1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-,methyl ester, (7bR,8aS)-
Cyclopropa[c]pyrrolo[3,2-e]indole-6-carboxylicacid,1,2,4,5,8,8a-hexahydro-4-oxo-2-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-
Duocarmycin SA
Cyclopropacpyrrolo3,2-eindole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl-, methyl ester, (7bR)-
methyl (3bR,4aS)-8-oxo-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-1,4,4a,5,6,8-hexahydrocyclopropa[c]pyrrolo[3,2-e]indole-2-carboxylate
Antibiotic DC 113

MDL Number

MFCD00870411

FAQ

What regulatory guidelines apply to Duocarmycin SA (CAS: 130288-24-3)?

Duocarmycin SA (CAS: 130288-24-3) falls under the jurisdiction of various regulatory guidelines, including GHS classification for handling and labeling, REACH regulations for EU market entry, and FDA/EPA requirements for safety and environmental impact. Compliance with these guidelines ensures proper management and use in research and industrial applications.

Are there alternatives to Duocarmycin SA (CAS: 130288-24-3) in synthesis?

Several alternatives to Duocarmycin SA (CAS: 130288-24-3) exist in synthesis, including analogs and isomers that offer similar biological activities. Common alternative reagents include other DNA-binding agents and chemically modified derivatives that may improve solubility or reduce toxicity, providing flexibility in medicinal chemistry approaches.

What is the market or research trend for Duocarmycin SA (CAS: 130288-24-3)?

The market trend for Duocarmycin SA (CAS: 130288-24-3) reflects growing interest in its potential as an anticancer agent. Research trends highlight advancements in its therapeutic applications, particularly in the treatment of leukemia and other hematological malignancies. Additionally, investigations into its mechanism of action and clinical trials continue to drive market dynamics.

How should waste containing Duocarmycin SA (CAS: 130288-24-3) be handled?

Handling waste containing Duocarmycin SA (CAS: 130288-24-3) requires careful attention to minimize environmental impact. Waste liquids should be collected and disposed of through incineration or professional waste disposal services. Environmental protection measures include proper containment to prevent spills and ensuring compliance with local hazardous waste regulations to safeguard public health and the environment.