Levocetirizine dihydrochloride

Basic Information

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CAS Number

130018-87-0

Molecular Formula

C21H27Cl3N2O3

Molecular Weight

461.81 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

211.0 to 215.0 deg-C

Boiling Point

542.1 °C at 760 mmHg

Flash Point

281.6 °C

Solubility

H2O: ≥23mg/mL

Specific Rotation

-12.79° (c=1, H2O)

SMILES

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OC(=O)COCCN1CCN(CC1)[C@@H](c1ccc(cc1)Cl)c1ccccc1.Cl.Cl

InChI

InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1

InChIKey

PGLIUCLTXOYQMV-GHVWMZMZSA-N

LogP

3.9918000000000045

Topological Polar Surface Area

53.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

443

Safety Information

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GHS Hazard Pictograms

H302

H400

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

Levocetirizine dihydrochloride
Levocetirizine
LEVOCETIRIZINE 2HCL
LEVOCETIRIZINE DIHCL
LEVOCETIRIZINE HCL
LEVOCETRIZINE DIHYDROCHLORIDE
[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
LevocetrizineHCl
LEVOCITIRIZINE DIHYDROCHLORIDE
Levo cetirzine dihydrochloride
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid hydrochloride
Levocetirizine diHCl
(-)-Cetirizine dihydrochloride
2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride
DDDB
Levocitirizine 2HCL
(R)-Form dihydrochloride
2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
(R) -2-[2-[4-[(4-Chlorophenyl) Phenylmethyl] Piperazin-1-yl]Ethoxy]Acetic Acid Dihydrochloride
(R)-Cetirizine dihydrochloride
(-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
LEVOCETIRIZINE DIHYDROCHLORIDE
(R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy) acetic acid
hydrochloride (1:2)

MDL Number

MFCD07366507

Customs Code

2933990090

FAQ

What is Levocetirizine dihydrochloride (CAS: 130018-87-0)?

Levocetirizine dihydrochloride (CAS: 130018-87-0) is an antihistamine compound used in pharmaceutical applications. Its chemical formula is C18H23ClN2O3·HCl, and it is a white to off-white crystalline powder with good solubility in water. It is commonly used as an active pharmaceutical ingredient in over-the-counter medications for allergies and is known for its efficacy and reduced sedative effects compared to other antihistamines.

What are the main uses of Levocetirizine dihydrochloride (CAS: 130018-87-0)?

Levocetirizine dihydrochloride (CAS: 130018-87-0) is primarily used in the treatment of allergic rhinitis, urticaria, and other allergy-related conditions. It is also found in combination medications for cold symptoms and nasal congestion. Its application in pharmaceuticals makes it a key component in antihistamine drugs, and it is recognized for its effectiveness in managing allergy symptoms with minimal side effects.

Is Levocetirizine dihydrochloride (CAS: 130018-87-0) safe?

Levocetirizine dihydrochloride (CAS: 130018-87-0) is considered safe when used as directed. It is generally well-tolerated, but precautions should be taken to avoid overdose or misuse. Safety standards ensure its quality and purity for pharmaceutical use, and handling should follow standard laboratory practices to minimize exposure risks.

How should Levocetirizine dihydrochloride (CAS: 130018-87-0) be stored?

Levocetirizine dihydrochloride (CAS: 130018-87-0) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to prevent moisture absorption and maintain stability. Proper storage conditions are essential to preserve its potency and ensure safe handling during pharmaceutical manufacturing and research processes.