Verteporfin | CAS No. 129497-78-5

Verteporfin

Basic Information

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CAS Number

129497-78-5

Molecular Formula

C41H42N4O8

Molecular Weight

718.79 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

°Cat760mmHg

SMILES

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COC(=O)CCC1=C(C)C2=N/C/1=C\c1[nH]c(c(c1CCC(=O)O)C)/C=C/1\N=C(/C=c/3\[nH]/c(=C\2)/c(C=C)c3C)C2=CC=C([C@H]([C@@]12C)C(=O)OC)C(=O)OC

InChI

InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)24(11-14-36(46)47)32(44-30)18-33-25(12-15-37(48)51-6)21(3)28(43-33)16-31(23)42-29/h9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/t38-,41+/m0/s1

InChIKey

CABKTHJNHVBKCC-ZSFNYQMMSA-N

LogP

6.719240000000006

Topological Polar Surface Area

173.55999999999997 Å²

Hydrogen Bond Donor/Acceptor

3 / 12

Complexity

1500

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

自购买之日起 2 年内稳定。其DMSO 溶液可在 -20°C 下保存长达 3 个月。

Synonyms & References

English

Verteporfin(DB00460)
Verteprofin
Visudyne
Verteporfin
Verteporphin
24H,26H-Benzo[b]porphine-9,13-dipropanoic acid, 18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-, monomethyl ester, (4R,4aS)-rel-
VERTEPIRFIN
9-methyl (I)13-methyl (II)trans-(±)- 18-ethenyl- 4,4a-dihydro-3,4 -bis(methoxycarbonyl)- 4a,8,14,19-tetramethyl- 23H,25H-benzo[b]porphine- 9,13- dipropanoate
trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester
CL 318952
VERTEPORFIN (200 MG)
3-[(23S,24R)-14-Ethenyl-5-(3-methoxy-3-oxopropyl)-22,23-bis(methoxycarbonyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-9-yl]propanoic acid
(4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-Benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

MDL Number

MFCD11982858

Customs Code

2933997500

FAQ

What is Verteporfin (CAS: 129497-78-5)?

Verteporfin is a photosensitizing agent used in the treatment of wet age-related macular degeneration (wAMD) and is also used in photodynamic therapy (PDT). It has a chemical formula of C32H25N5NaO5S and is a light-activated compound.

What are the main uses of Verteporfin (CAS: 129497-78-5)?

Verteporfin is primarily used in the treatment of wet age-related macular degeneration (wAMD) and photodynamic therapy (PDT) for various ocular conditions. It is also used in the treatment of certain types of skin cancers and has potential applications in the field of oncology.

Is Verteporfin (CAS: 129497-78-5) safe?

Verteporfin is generally safe when used under medical supervision. However, it can cause phototoxicity, leading to severe sunburn if exposed to light. Proper protective measures, such as wearing UV-blocking sunglasses and avoiding sunlight, are necessary. Toxicity and other safety considerations must be followed strictly as per medical guidelines.

How should Verteporfin (CAS: 129497-78-5) be stored?

Verteporfin should be stored in a cool, dry place away from direct sunlight and heat. It should be kept in a tightly sealed container to prevent degradation. Avoid freezing. The storage conditions should be maintained at a temperature below 25°C (77°F) and with a relative humidity below 60%. Proper labeling and storage in a secure area are recommended to prevent accidental exposure. Only use the compound after verifying its stability and within the recommended time frame as per the manufacturer's guidelines.