Romidepsin | CAS No. 128517-07-7

Romidepsin

Basic Information

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CAS Number

128517-07-7

Molecular Formula

C24H36N4O6S2

Molecular Weight

540.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

No data available

Melting Point

219-224°C

Boiling Point

942.8°C at 760 mmHg

Flash Point

524°C

Refractive Index

1.529

SMILES

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CC=C1C(=O)NC(C(=O)OC2CC(=O)NC(C(=O)NC(CSSCCC=C2)C(=O)N1)C(C)C)C(C)C

InChI

InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7-,16-6-/t15-,17-,19-,20+/m1/s1

InChIKey

OHRURASPPZQGQM-QDBHDZETSA-N

LogP

1.4296000000000009

Topological Polar Surface Area

142.70000000000002 Å²

Hydrogen Bond Donor/Acceptor

4 / 10

Complexity

905

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXCID8028505
ROMIDEPSIN [WHO-DD]
Romidepsin; FK-228
SR-01000941579
HDInhib_000006
HY-15149
D06637
(E)-(1S,10S,21R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2- oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Romidepsin
Romidepsin [USAN]
L-Valine,3-didehydro-2-aminobutanoyl-,.xi.-lactone, cyclic (1.fwdarw.2)-disulfide
CS-0985
NSC-754143
(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone
Romidepsin (FK228)
ROMIDEPSIN [MART.]
BDBM19151
L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide
MFCD18433404
SR-01000941579-1
FK228
DB06176
ROMIDEPSIN [MI]
AB01273968-01
CHEBI:61080
GTPL7006
Probes1_000153
FR901228
FK-901228
Probes2_000337
Istodax

MDL Number

MFCD18433404

FAQ

What is Romidepsin (CAS: 128517-07-7)?

Romidepsin, also known as FP-3339A, is a potent and selective histone deacetylase inhibitor with the chemical formula C24H26N2O5. It is used in the treatment of cutaneous T-cell lymphoma and is under investigation for other diseases. Romidepsin is a white to off-white powder that is poorly soluble in water and soluble in organic solvents.

What are the main uses of Romidepsin (CAS: 128517-07-7)?

Romidepsin is primarily used in the treatment of cutaneous T-cell lymphoma. It is also being investigated for its potential applications in other hematologic malignancies and solid tumors. Romidepsin is a key compound in pharmaceutical research for epigenetic modulation and cancer therapy.

Is Romidepsin (CAS: 128517-07-7) safe?

Romidepsin is generally safe when used under medical supervision. However, it can cause side effects such as nausea, fatigue, and peripheral neuropathy. Proper training and adherence to safety protocols are essential to ensure safety. Patients should avoid contact with the skin and eyes and use appropriate protective equipment during administration and handling.

How should Romidepsin (CAS: 128517-07-7) be stored?

Romidepsin should be stored in a tightly sealed container at room temperature (15-30°C) and protected from light. It should be kept away from moisture and heat. The container should be stored in a dry place and protected from direct sunlight. Proper labeling and storage conditions are critical to maintain the stability and efficacy of Romidepsin.