Colistin sulfate

Basic Information

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CAS Number

1264-72-8

Molecular Formula

C52H98N16O13

Molecular Weight

1155.46 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

200-220 ºC

Water Solubility

Soluble in water

Solubility

H2O: soluble50mg/mL

SMILES

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CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O

InChI

InChI=1S/C52H98N16O13/c1-9-29(6)11-10-12-40(71)59-32(13-19-53)47(76)68-42(31(8)70)52(81)64-35(16-22-56)44(73)63-37-18-24-58-51(80)41(30(7)69)67-48(77)36(17-23-57)61-43(72)33(14-20-54)62-49(78)38(25-27(2)3)66-50(79)39(26-28(4)5)65-45(74)34(15-21-55)60-46(37)75/h27-39,41-42,69-70H,9-26,53-57H2,1-8H3,(H,58,80)(H,59,71)(H,60,75)(H,61,72)(H,62,78)(H,63,73)(H,64,81)(H,65,74)(H,66,79)(H,67,77)(H,68,76)/t29?,30-,31-,32+,33+,34+,35+,36+,37+,38+,39-,41+,42+/m1/s1

InChIKey

YKQOSKADJPQZHB-QNPLFGSASA-N

LogP

-5.831499999999969

Topological Polar Surface Area

490.6599999999998 Å²

Hydrogen Bond Donor/Acceptor

23 / 29

Complexity

2130

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

colistin sulfate
n-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate
Colistin Sulphate
Colistin Sulfate (mixture)
Colistin sulfate (USP Grade)
Colistin sulfate salt
Polymyxin E Sulfate
Colistin sulfate salt,Polymyxin E
Polymyxin E
Polymyxin?E
Polymyxin E
N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-
Colistin sulfate

MDL Number

MFCD27976775

Customs Code

2309901000

FAQ

What is Colistin sulfate (CAS: 1264-72-8)?

Colistin sulfate is an antibiotic compound with the CAS number 1264-72-8. It is a sulfate salt of colistin, a cyclic lipopeptide antibiotic primarily used for treating serious gram-negative bacterial infections. Colistin sulfate has a molecular formula of C₃₄H₆₃NO₁₃S₂ and is known for its cationic surfactant properties, which contribute to its antimicrobial activity. It is commonly available as a powder or solution and is used in veterinary medicine and human healthcare.

What are the main uses of Colistin sulfate (CAS: 1264-72-8)?

Colistin sulfate (CAS: 1264-72-8) is primarily used in veterinary medicine to treat bacterial infections in animals, especially in poultry and swine. It is also employed in human medicine for severe infections caused by multidrug-resistant gram-negative bacteria. Additionally, it finds applications in research for studying antimicrobial mechanisms and in industrial settings for producing pharmaceutical products. Its use in food production is limited to specific therapeutic contexts under regulatory guidelines.

Is Colistin sulfate (CAS: 1264-72-8) safe?

Colistin sulfate (CAS: 1264-72-8) is generally considered safe when used as directed, but it requires careful handling due to its potential toxicity. Prolonged use or high doses may lead to nephrotoxicity and neurotoxicity. Safety standards emphasize proper dosing, monitoring, and adherence to guidelines to minimize adverse effects. Protective measures include using personal protective equipment and following standard operating procedures for handling pharmaceutical compounds.

How should Colistin sulfate (CAS: 1264-72-8) be stored?

Colistin sulfate (CAS: 1264-72-8) should be stored in a cool, dry place away from direct sunlight. It is typically kept in airtight containers to prevent moisture absorption and degradation. The recommended storage temperature is between 15°C to 25°C, and it should be protected from humidity and light exposure. Proper storage ensures stability and maintains the compound's effectiveness over time.