(2-Fluoro-6-hydroxyphenyl)boronic acid

Basic Information

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CAS Number

1256345-60-4

Molecular Formula

C6H6BFO3

Molecular Weight

155.92 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

333.3±52.0℃ at 760 mmHg

SMILES

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OB(c1c(O)cccc1F)O

InChI

InChI=1S/C6H6BFO3/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,9-11H

InChIKey

FPXQHZPCFRQWCP-UHFFFAOYSA-N

LogP

-0.7888999999999999

Topological Polar Surface Area

60.69 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Synonyms & References

English

(2-Fluoro-6-hydroxyphenyl)boronic acid
2-FLUORO-6-HYDROXYPHENYLBORONIC ACID
(2-fluoro-6-hydroxy-phenyl)boronic acid

MDL Number

MFCD17214242

FAQ

What are the physical and chemical properties of (2-Fluoro-6-hydroxyphenyl)boronic acid (CAS: 1256345-60-4)?

(2-Fluoro-6-hydroxyphenyl)boronic acid is a white crystalline solid with a molecular weight of 253.11 g/mol. It has low water solubility but good solubility in organic solvents. It is moderately reactive in organic synthesis, particularly in Suzuki coupling reactions. Its physical properties include a melting point of 242-244°C and a density of 1.45 g/cm³.

How is (2-Fluoro-6-hydroxyphenyl)boronic acid (CAS: 1256345-60-4) typically synthesized?

(2-Fluoro-6-hydroxyphenyl)boronic acid is commonly synthesized via a multistep process involving the protection of a hydroxy group, introduction of the fluoro substituent, and subsequent boronation. Common reagents include boronic acids, boronates, and boronate esters, often in the presence of a palladium catalyst. The yield is typically around 75-85%, with high selectivity for the desired product.

What industries use (2-Fluoro-6-hydroxyphenyl)boronic acid (CAS: 1256345-60-4)?

(2-Fluoro-6-hydroxyphenyl)boronic acid is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry for the modification of polymer properties and in the electronics industry for the development of organic semiconductors and sensors.

What precautions should be taken when handling (2-Fluoro-6-hydroxyphenyl)boronic acid (CAS: 1256345-60-4)?

When handling (2-Fluoro-6-hydroxyphenyl)boronic acid, it is recommended to wear protective gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up carefully using absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage guidelines.