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6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide | CAS No. 1254053-43-4

6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide

Basic Information

Chemical_Structure_Of
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CAS Number

1254053-43-4

Molecular Formula

C29H44N8O3

Molecular Weight

552.72 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids
Basic Chemical Raw Materials Organic Chemicals Ethers
Basic Chemical Raw Materials Organic Chemicals Amines
Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Fine Chemicals Surfactants Anionic Surfactants
Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCc1c(nc(c(n1)C(=O)N)Nc2ccc(c(c2)OC)N3CCC(CC3)N4CCN(CC4)C)NC5CCOCC5

InChI

InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

InChIKey

GYQYAJJFPNQOOW-UHFFFAOYSA-N

LogP

2.6972000000000014

Topological Polar Surface Area

121.11 Ų

Hydrogen Bond Donor/Acceptor

4 / 11

Complexity

785

Synonyms & References

English

  • Gilteritinib
  • 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
  • ASP 2215
  • ASP2215
  • Xospata
  • 6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide
  • 66D92MGC8M
  • 2-Pyrazinecarboxamide, 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-
  • 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
  • 2-Pyrazinecar
  • 6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide

MDL Number

MFCD28144685

FAQ

What regulatory guidelines apply to 6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide (CAS: 1254053-43-4)?
The chemical is subject to regulatory guidelines under the Chemicals Regulation Directive (CRD) and Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) in the EU. In the US, it falls under the Toxic Substances Control Act (TSCA) and may require reporting to the EPA. Safety data sheets (SDS) should be prepared and maintained according to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) standards.

Are there alternatives to 6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide (CAS: 1254053-43-4) in synthesis?
In synthesis, alternatives such as 6-ethyl-3-(3-methoxy-4-phenylamino-4-(4-methyl-1-piperazinyl)-1-piperidinyl)pyrazine-5-carboxylic acid tetrahydro-2H-pyran-4-ylamide and 6-ethyl-3-(3-methoxy-4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenylamino)-5-carbamoyl)-2-pyrazine carboxylic acid may serve as substitutes. Additionally, using different coupling agents or modifying the synthesis route can also provide alternative options.

What is the market or research trend for 6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide (CAS: 1254053-43-4)?
The market for 6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide is currently driven by its potential in treating various neurological and psychiatric disorders. Research trends indicate a focus on optimizing its pharmacokinetics and exploring new therapeutic applications. The increasing demand for personalized medicine and drug repurposing is also likely to influence market dynamics.

How should waste containing 6-Ethyl-3-({3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)-2-pyrazinecarboxamide (CAS: 1254053-43-4) be handled?
Waste containing this compound should be collected in appropriate containers, labeled with the chemical's name and CAS number, and stored in a secure and well-ventilated area. Proper disposal methods include incineration or professional waste disposal services. Environmental protection precautions include ensuring no spillage and using personal protective equipment. Always adhere to local and national regulations for the safe handling and disposal of hazardous waste.

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