Azelnidipine | CAS No. 123524-52-7

Azelnidipine

Basic Information

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CAS Number

123524-52-7

Molecular Formula

C33H34N4O6

Molecular Weight

582.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

120-126 ºC

Boiling Point

709.3°C at 760 mmHg

Density

1.33

Flash Point

709.3oCat 760 mmHg

Solubility

DMSO: >10mg/mL

Refractive Index

1.658

SMILES

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CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C

InChI

InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

InChIKey

ZKFQEACEUNWPMT-UHFFFAOYSA-N

LogP

6.18470

pKa

7.89(at 25℃)

Complexity

1080

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Sensitiveness

对空气敏感

Toxicity

LD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally

Synonyms & References

English

RS-9054
3-(1-(DIPHENYLMETHYL)-3-AZETIDINYL) 5-ISOPROPYL (+/-)-2-AMINO-1,4-DIHYDRO-6-METHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
FT-0655294
A805113
123524-52-7
SR-01000944916-1
Azelnidipine (JP17/INN)
SCHEMBL49021
2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl)ester 5-isopropyl ester
SR-01000944916
2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
CHEBI:31247
C33H34N4O6
BCPP000357
AC-2151
DTXSID3020120
PB24693
AMY22122
CS-0949
3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
KS-1248
AKOS015841674
NCGC00167436-02
AZELNIDIPINE [MART.]
PV23P19YUG
CS-905
Tox21_112440
AZELNIDIPINE [JAN]
Azelnidipine
AB01565841_02
3,5-PYRIDINEDICARBOXYLIC ACID, 2-AMINO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-, 3-[1-(DIPHENYLMETHYL)-3-AZETIDINYL] 5-(1-METHYLETHYL) ESTER

MDL Number

MFCD00865803

Customs Code

2933990090

FAQ

What is Azelnidipine (CAS: 123524-52-7)?

Azelnidipine (CAS: 123524-52-7) is a calcium channel blocker used primarily in the treatment of hypertension. It has the chemical formula C21H26N2O6 and is known for its ability to relax blood vessels, improving blood flow and reducing blood pressure. It is a white to pale yellow crystalline powder with good solubility in certain solvents and is commonly used in pharmaceutical formulations.

What are the main uses of Azelnidipine (CAS: 123524-52-7)?

Azelnidipine (CAS: 123524-52-7) is mainly used as an antihypertensive agent to manage high blood pressure. It is also prescribed for the treatment of angina pectoris and coronary artery disease. In research settings, it serves as a tool for studying calcium channel regulation. Its applications are well-documented in pharmaceutical and medical literature, making it a key compound in cardiovascular therapy.

Is Azelnidipine (CAS: 123524-52-7) safe?

Azelnidipine (CAS: 123524-52-7) is generally considered safe when used as directed in medical treatments. However, it should be handled with care, and proper safety measures must be followed during storage and use. As with any pharmaceutical compound, it is important to follow safety guidelines and consult healthcare professionals for appropriate use and potential side effects.

How should Azelnidipine (CAS: 123524-52-7) be stored?

Azelnidipine (CAS: 123524-52-7) should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature below 25°C and with humidity levels below 60%. Proper storage ensures the stability and potency of the compound, preventing degradation and maintaining its efficacy for pharmaceutical use.