(4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline

Basic Information

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CAS Number

122996-47-8

Molecular Formula

C24H27NO5

Molecular Weight

409.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

59.0 to 64.0 deg-C

Specific Rotation

-25±2.5° (c=1%,in methanol)

SMILES

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CC(C)(C)OC1CC(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

InChI

InChI=1S/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15-,21+/m1/s1

InChIKey

WPBXBYOKQUEIDW-VFNWGFHPSA-N

LogP

4.278100000000003

Topological Polar Surface Area

76.07 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

622

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

(2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylic acid
F1095
fmoc-4-tert-butoxy-l-proline
N-alpha-Fmoc-O-tert-butyl-L-trans-4-hydroxyproline
J-004880
SCHEMBL118220
HY-W010964
FMOC- Hyp(tBu)- OH
AS-17468
(2S,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxy)pyrrolidine-2-carboxylicacid
Fmoc-O-tert.butyl-trans-4-hydroxy-L-proline
N-Fmoc-4-trans-(tert-butoxy)-L-proline
Fmoc-D-Hyp(tBu)-OH
Trans-N-Fmoc-4-(tert-butoxy)-L-proline
WPBXBYOKQUEIDW-VFNWGFHPSA-N
CS-W011680
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-trans-(tert-butoxy)-L-proline
Fmoc-(2S,4R)-(-)-4-t-butoxypyrrolidine-2-carboxylic acid
Fmoc-O-tert-butyl-L-hydroxyproline
(2S,4R)-4-(tert-butoxy)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
Fmoc-Hyp(OtBu)-OH
Z2044808427
Fmoc-Hyp(tBu)-OH, >=98.0% (HPLC)
1,2-Pyrrolidinedicarboxylic acid, 4-(1,1-dimethylethoxy)-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4R)-
(2S,4R)-4-(tert-butoxy)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid
Fmoc-L-Hyp(tBu)-OH
A20638
FD21786
AM81837
122996-47-8
Fmoc-Hyp(OtBu)OH

MDL Number

MFCD00151930

FAQ

What are the physical and chemical properties of (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline (CAS: 122996-47-8)?

(4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline is a crystalline compound with a molecular weight of approximately 494.52 g/mol. It is soluble in organic solvents such as dichloromethane and methanol. The compound shows good reactivity in esterification and amide formation reactions.

How is (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline (CAS: 122996-47-8) typically synthesized?

(4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline is typically synthesized via a multi-step process involving the protection of the L-proline with fluorenylmethoxycarbonyl (Fmoc) group, followed by the introduction of the 2-methyl-2-propanol moiety. The synthesis involves the use of catalytic amounts of a suitable reagent and is known to have good yield and selectivity.

What industries use (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline (CAS: 122996-47-8)?

(4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline is primarily used in the pharmaceutical industry for the synthesis of complex molecules and in polymer industry for the development of new materials with specific properties.

What precautions should be taken when handling (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline (CAS: 122996-47-8)?

When handling (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[(2-methyl-2-propanyl)oxy]-L-proline, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety glasses. The compound should be stored in a cool, dry place away from direct sunlight. In case of spill, neutralize the spill with an appropriate reagent and dispose of the waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.