5-Chloro-6-(trifluoromethyl)pyridin-2-amine

Basic Information

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CAS Number

1227595-72-3

Molecular Formula

C6H4ClF3N2

Molecular Weight

196.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1=CC(=NC(=C1Cl)C(F)(F)F)N

InChI

InChI=1S/C6H4ClF3N2/c7-3-1-2-4(11)12-5(3)6(8,9)10/h1-2H,(H2,11,12)

InChIKey

VPVLDKKSLCMFPO-UHFFFAOYSA-N

LogP

2.3360000000000003

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

161

Synonyms & References

English

5-Chloro-6-(trifluoromethyl)pyridin-2-amine
5-Chloro-6-trifluoromethyl-pyridin-2-ylamine
DTXSID40858623
AB70889
SY288713
5-Chloro-6-(trifluoromethyl)pyridin-2-ylamine
6-AMINO-3-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE
AKOS022176143
EN300-226238
SCHEMBL19456705
2-Amino-5-chloro-6-(trifluoromethyl)pyridine
CS-0029842
5-CHLORO-6-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE
AS-66624
1227595-72-3
Z1255448440
2-Pyridinamine, 5-chloro-6-(trifluoromethyl)-
AMY3193
W16815
VPVLDKKSLCMFPO-UHFFFAOYSA-N
MFCD16606147
DB-263539

MDL Number

MFCD16606147

FAQ

What are the physical and chemical properties of 5-Chloro-6-(trifluoromethyl)pyridin-2-amine (CAS: 1227595-72-3)?

5-Chloro-6-(trifluoromethyl)pyridin-2-amine is a crystalline solid with a molecular weight of approximately 263.03 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and DMSO. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions.

How is 5-Chloro-6-(trifluoromethyl)pyridin-2-amine (CAS: 1227595-72-3) typically synthesized?

5-Chloro-6-(trifluoromethyl)pyridin-2-amine is commonly synthesized via the amination of 5-chloro-6-(trifluoromethyl)pyridine with an amine reagent. This process often involves the use of triethylamine as a base and is carried out under mild conditions. The yield is typically around 85-90%.

What industries use 5-Chloro-6-(trifluoromethyl)pyridin-2-amine (CAS: 1227595-72-3)?

5-Chloro-6-(trifluoromethyl)pyridin-2-amine finds applications in pharmaceuticals for the synthesis of certain drug intermediates. It is also used in the chemical industry for the development of new materials and in sensor technologies where its unique chemical properties are utilized.

What precautions should be taken when handling 5-Chloro-6-(trifluoromethyl)pyridin-2-amine (CAS: 1227595-72-3)?

When handling 5-Chloro-6-(trifluoromethyl)pyridin-2-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of fumes. In case of a spill, immediately clean up with appropriate absorbent material and follow the safety data sheet (SDS) guidelines for disposal.