5-Chloro-6-(trifluoromethyl)pyridin-2-amine(CAS: 1227595-72-3)

5-Chloro-6-(trifluoromethyl)pyridin-2-amine is a crystalline solid with a molecular weight of approximately 263.03 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and DMSO. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions.

5-Chloro-6-(trifluoromethyl)pyridin-2-amine is commonly synthesized via the amination of 5-chloro-6-(trifluoromethyl)pyridine with an amine reagent. This process often involves the use of triethylamine as a base and is carried out under mild conditions. The yield is typically around 85-90%.

5-Chloro-6-(trifluoromethyl)pyridin-2-amine finds applications in pharmaceuticals for the synthesis of certain drug intermediates. It is also used in the chemical industry for the development of new materials and in sensor technologies where its unique chemical properties are utilized.

When handling 5-Chloro-6-(trifluoromethyl)pyridin-2-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of fumes. In case of a spill, immediately clean up with appropriate absorbent material and follow the safety data sheet (SDS) guidelines for disposal.