2-Bromo-3-chloro-5-fluoropyridine

Basic Information

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CAS Number

1214326-94-9

Molecular Formula

C5H2BrClFN

Molecular Weight

210.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

200.2±35.0 ºC (760 Torr),

Flash Point

74.9±25.9 ºC,

SMILES

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C1=C(C=NC(=C1Cl)Br)F

InChI

InChI=1S/C5H2BrClFN/c6-5-4(7)1-3(8)2-9-5/h1-2H

InChIKey

NWCUOFUVPZPBKW-UHFFFAOYSA-N

LogP

2.6366000000000005

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

103

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Bromo-3-chloro-5-fluoropyridine
C5H2BrClFN
AB66730
AK122817
AM62484
BL010137
KB-82005
QC-7015
3820AA
Pyridine, 2-bromo-3-chloro-5-fluoro-
AB0087209
2-Bromo-3-chloro-5-fluoro-pyridine
2-bromo-3-chloro-5-fluoro-pyridine
AS-813/43501983
CS-0157376
2-bromo-3-chloro-5-fluoropyridine
SY068673
DB-127626
EN300-132544
DTXSID70742642
1214326-94-9
MFCD13185350
AKOS016012251
2-Bromo-3-chloro-5-fluoropyridine, 95%
AS-45777
A854440
SCHEMBL17239620

MDL Number

MFCD13185350

FAQ

What are the physical and chemical properties of 2-Bromo-3-chloro-5-fluoropyridine (CAS: 1214326-94-9)?

2-Bromo-3-chloro-5-fluoropyridine is a crystalline solid with a molecular weight of approximately 228.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly in the presence of strong bases or reducing agents. It can undergo substitution reactions and is often used as a precursor in organic synthesis.

How is 2-Bromo-3-chloro-5-fluoropyridine (CAS: 1214326-94-9) typically synthesized?

2-Bromo-3-chloro-5-fluoropyridine is typically synthesized through electrophilic aromatic substitution reactions. A common method involves the substitution of a pyridine ring with bromine followed by the introduction of a chlorine atom and a fluorine atom. Catalysts such as fuming sulfuric acid or Lewis acids are often used to enhance the reactivity and selectivity of the reactions.

What industries use 2-Bromo-3-chloro-5-fluoropyridine (CAS: 1214326-94-9)?

2-Bromo-3-chloro-5-fluoropyridine is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds applications in the polymer industry for the development of new materials with specific properties. Additionally, it is used in sensor technology and semiconductor manufacturing, although to a lesser extent compared to its pharmaceutical applications.

What precautions should be taken when handling 2-Bromo-3-chloro-5-fluoropyridine (CAS: 1214326-94-9)?

When handling 2-Bromo-3-chloro-5-fluoropyridine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure to harmful vapors. Spills should be cleaned up immediately using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.