DEFENSIN HNP-2 (HUMAN)

Basic Information

View in Editor

CAS Number

120721-97-3

Molecular Formula

C147H217N43O37S6

Molecular Weight

3370.95 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

View in Editor

S1C[C@H]2C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3C=CC(=CC=3)O)C(NCC(N[C@@H]([C@@H](C)O)C(N[C@@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CCCNC(=N)N)C(N[C@H](C(N[C@@H](CC4=CNC5C=CC=CC4=5)C(N[C@@H](C)C(N[C@@H](CC4C=CC=CC=4)C(N[C@H](C(N[C@H](C(=O)O)CSSC[C@@H](C(N[C@@H](CC4C=CC(=CC=4)O)C(N[C@@H](CSSC3)C(N[C@@H](CCCNC(=N)N)C(N[C@@H]([C@@H](C)CC)C(N3CCC[C@H]3C(N[C@H](C(N2)=O)C)=O)=O)=O)=O)=O)=O)N)=O)CS1)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CCC(N)=O)=O)CC1C=CC(=CC=1)O)=O)[C@@H](C)CC)=O)=O)=O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(=O)O)=O)=O)C)=O)[C@@H](C)CC)=O

InChI

1S/C147H217N43O37S6/c1-13-73(6)114-139(222)168-76(9)118(201)163-63-110(196)170-96(48-50-113(199)200)127(210)172-92(31-22-52-159-145(152)153)125(208)171-93(32-23-53-160-146(154)155)126(209)178-98(58-81-35-41-85(192)42-36-81)123(206)165-65-112(198)186-117(79(12)191)141(224)184-106-70-232-229-67-103-134(217)173-94(33-24-54-161-147(156)157)128(211)189-116(75(8)15-3)142(225)190-55-25-34-108(190)138(221)167-78(11)120(203)181-105(136(219)187-114)69-231-230-68-104(135(218)185-107(143(226)227)71-233-228-66-89(148)121(204)176-100(133(216)182-103)59-82-37-43-86(193)44-38-82)183-132(215)99(57-80-26-17-16-18-27-80)175-119(202)77(10)166-129(212)102(61-84-62-162-90-29-20-19-28-88(84)90)179-130(213)97(56-72(4)5)177-124(207)91(30-21-51-158-144(150)151)169-111(197)64-164-122(205)95(47-49-109(149)195)174-131(214)101(60-83-39-45-87(194)46-40-83)180-140(223)115(74(7)14-2)188-137(106)220/h16-20,26-29,35-46,62,72-79,89,91-108,114-117,162,191-194H,13-15,21-25,30-34,47-61,63-71,148H2,1-12H3,(H2,149,195)(H,163,201)(H,164,205)(H,165,206)(H,166,212)(H,167,221)(H,168,222)(H,169,197)(H,170,196)(H,171,208)(H,172,210)(H,173,217)(H,174,214)(H,175,202)(H,176,204)(H,177,207)(H,178,209)(H,179,213)(H,180,223)(H,181,203)(H,182,216)(H,183,215)(H,184,224)(H,185,218)(H,186,198)(H,187,219)(H,188,220)(H,189,211)(H,199,200)(H,226,227)(H4,150,151,158)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t73-,74-,75-,76-,77-,78-,79+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,114-,115-,116-,117-/m0/s1

InChIKey

GRZXCHIIZXMEPJ-HTLKCAKFSA-N

LogP

-8.822019999999963

Topological Polar Surface Area

1294.0300000000002 Å²

Hydrogen Bond Donor/Acceptor

54 / 80

Complexity

7750

Synonyms & References

English

Defensin HNP-2 (human)
Defensin HNP-2 (human), Human Neutrophil Peptide-2, HNP-2
HUMAN NEUTROPHIL PEPTIDE-2
L-Cysteine,L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cystein...
L-Cysteine,L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L
L-Cysteine,L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L-a-glutamyl-L-arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-cysteinyl-L-is
28)-tris(disulfide)
29),(3&reg
HuMan Neutrophil Peptide-2, HNP-2
Defensin HNP-2 (huMan) HuMan Neutrophil Peptide-2, HNP-2
H-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH
Neutrophil Peptide-2
Defensin HNP-2 human
Defensin HNP-2
.alpha.-Defensin-2
HNP2
HNP-2
PUBCHEM_16130867
Defensin HNP-2 (human) trifluoroacetate salt
Human .alpha.defensin-2 (Human .alpha.defensin NP 2)
H-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-G

MDL Number

MFCD00076222

FAQ

What is DEFENSIN HNP-2 (CAS: 120721-97-3)?

DEFENSIN HNP-2 is a human antimicrobial peptide involved in the innate immune system. It has a molecular weight of approximately 4.5 kDa and consists of 27 amino acids. This compound is amphipathic and exhibits potent antimicrobial and anti-inflammatory activities.

What are the main uses of DEFENSIN HNP-2 (CAS: 120721-97-3)?

DEFENSIN HNP-2 is primarily used in research for studying innate immunity and antimicrobial peptides. It is also explored for potential therapeutic applications in treating infections and inflammation.

Is DEFENSIN HNP-2 (CAS: 120721-97-3) safe?

DEFENSIN HNP-2 is generally considered safe for research use when handled with standard laboratory precautions. However, it is recommended to follow safety guidelines due to its antimicrobial activity. Direct contact with the eyes and skin should be avoided, and proper protective equipment should be worn.

How should DEFENSIN HNP-2 (CAS: 120721-97-3) be stored?

DEFENSIN HNP-2 should be stored at -20°C to -80°C in a freezer to maintain stability. Avoid repeated freeze-thaw cycles, and store it in a tightly sealed container to prevent contamination. Keep it away from light and ensure the storage area is secure and accessible only to authorized personnel.