Anastrozole | CAS No. 120511-73-1

Anastrozole

Basic Information

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CAS Number

120511-73-1

Molecular Formula

C17H19N5

Molecular Weight

293.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

81-82 ºC

Solubility

DMSO: soluble40mg/mL

SMILES

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CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N

InChI

InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3

InChIKey

YBBLVLTVTVSKRW-UHFFFAOYSA-N

LogP

2.92876

Complexity

456

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H360 May damage fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

Anastrozole
ICI-D-1033
ARIMIDEX
1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE
ANASTRAZOLE
tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile
ZD-1033
2,2'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)
Anastrozole (Arimidex)
Anatrozole
Anti-Estrogen AI Arimidex
1,3-benzenediacetonitrile
Anastrol
Anastrolozole
Anastrozol
ZD1033
ICI-D1033
a,a,a′,a′-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
MDPT
Astrozole
2;2"-[5-(1H-1;2;4-Triazol-1-ylmethyl)-1
3-Phenylene]bis(2-methyl-propiononitrile
zd
Anastrozole iMpurity
ZD 1033
ICI D1033
2Z07MYW1AZ
alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
YBBLVLTVTVSKRW-UHFFFAOYSA-N
C17H19N5

MDL Number

MFCD00866298

Customs Code

2933990090

FAQ

What is Anastrozole (CAS: 120511-73-1)?

Anastrozole is a non-steroidal aromatase inhibitor used primarily in the treatment of hormone receptor-positive breast cancer. Its chemical formula is C18H18F3NO. It is a white to off-white powder, slightly soluble in water, and has a molecular weight of 323.34 g/mol. Anastrozole works by reducing the amount of estrogen produced in the body, making it an important medication in oncology.

What are the main uses of Anastrozole (CAS: 120511-73-1)?

Anastrozole is mainly used in the pharmaceutical industry for treating postmenopausal women with hormone receptor-positive breast cancer. It is also utilized in research for studying estrogen-related pathways and in clinical trials for evaluating its efficacy in various cancer therapies. As an aromatase inhibitor, it has applications in hormonal treatments and drug development.

Is Anastrozole (CAS: 120511-73-1) safe?

Anastrozole is generally considered safe when used as directed, but it should be handled with care to avoid skin contact and inhalation. It is classified as a Category B drug by the FDA, indicating that animal studies show no risk to the fetus, but there are limited human studies. Safety measures include proper storage and use of personal protective equipment during handling.

How should Anastrozole (CAS: 120511-73-1) be stored?

Anastrozole should be stored in a cool, dry place away from direct light. It is typically kept in a tightly sealed container at a temperature range of 15–30°C. Proper storage helps maintain its chemical stability and potency. Avoid exposure to moisture and ensure it is stored in a secure location to prevent accidental ingestion or contamination.