Dorzolamide | CAS No. 120279-96-1

Dorzolamide

Basic Information

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CAS Number

120279-96-1

Molecular Formula

C10H16N2O4S3

Molecular Weight

324.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

575.8 °C at 760 mmHg

Density

1.53

Flash Point

302 °C

Solubility

DMSO: soluble5mg/mL (clear solution, warmed)

Refractive Index

1.626

SMILES

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CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C

InChI

InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1

InChIKey

IAVUPMFITXYVAF-XPUUQOCRSA-N

LogP

0.612

Topological Polar Surface Area

106.33 Å²

Hydrogen Bond Donor/Acceptor

3 / 6

Complexity

534

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Prestwick3_001116
Prestwick2_001116
BRD-K48617017-003-03-1
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
DB00869
AKOS005576255
SCHEMBL24061
DORZOLAMIDE [MI]
EN300-19766577
AB00514687
AS-14731
CS-1859
(2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1lambda6-thieno[2,3-b]thiopyran-6-sulfonamide
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide
DORZOLAMIDE [VANDF]
4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
SPBio_003116
AB00514687_08
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Prestwick0_001116
DTXSID7022960
4-ethylamino-5,6-dihydro-6-methyl-7,7-dioxide-4H-thieno(2,3-b)thiopyran-2-sulfonamide
UNII-9JDX055TW1
BIDD:GT0306
(4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno(2,3-b)thiopyran-2-sulfonamide 7,7-dioxide
DORZOLAMIDE [INN]
Dorzolamide (DZA)
4S,6S-Dorzolamide
4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno(2,3-b)thiopyran-2-sulfonic acid amide
120279-96-1
SR-05000001449

MDL Number

MFCD00865636

FAQ

What is Dorzolamide (CAS: 120279-96-1)?

Dorzolamide is an ophthalmic agent commonly used in the treatment of glaucoma. It is a carbonic anhydrase inhibitor with the chemical formula C11H16N2O3S. Dorzolamide is known for its ability to reduce intraocular pressure by inhibiting the enzyme carbonic anhydrase in the eye's trabecular meshwork.

What are the main uses of Dorzolamide (CAS: 120279-96-1)?

The main uses of Dorzolamide are in the management of glaucoma and ocular hypertension. It is available as an ophthalmic suspension and is used to lower intraocular pressure and reduce eye pain associated with increased intraocular pressure.

Is Dorzolamide (CAS: 120279-96-1) safe?

Dorzolamide is generally considered safe when used as prescribed for the treatment of glaucoma. However, like any medication, it may cause side effects such as burning or stinging in the eye, redness, and changes in taste. It is important to follow usage instructions and consult a healthcare provider if any adverse effects are experienced.

How should Dorzolamide (CAS: 120279-96-1) be stored?

Dorzolamide should be stored at room temperature, away from direct heat and light. It should be kept in a tightly closed container to prevent moisture and contamination. Avoid storing it in humid or damp environments to maintain its efficacy and safety.