tert-butyl N-[(2R)-2-hydroxypropyl]carbamate

Basic Information

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CAS Number

119768-44-4

Molecular Formula

C8H17NO3

Molecular Weight

175.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Physical Properties

Boiling Point

276.4℃ at 760 mmHg

Density

1.025

Flash Point

121°C

Refractive Index

1.4460

SMILES

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C[C@@H](O)CNC(=O)OC(C)(C)C

InChI

InChI=1S/C8H17NO3/c1-6(10)5-9-7(11)12-8(2,3)4/h6,10H,5H2,1-4H3,(H,9,11)/t6-/m1/s1

InChIKey

YNJCFDAODGKHAV-ZCFIWIBFSA-N

LogP

0.8919000000000001

Topological Polar Surface Area

58.56 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

151

Synonyms & References

English

(R)-tert-Butyl (2-hydroxypropyl)carbamate
(R)-1-(Boc-amino)-2-propanol
Boc-(R)-1-amino-2-propanol
N-BOC-(R)-1-AMINO-2-PROPANOL
N-T-BOC-(R)-1-AMINO-2-PROPANOL
tert-butyl [(2R)-2-hydroxypropyl]carbamate
tert-butyl N-[(2R)-2-hydroxypropyl]carbamate
1-t-butoxycarbonylamino-2-propanol
G-1210R
N-Boc-1-amino-2-propanol
N-tert-butoxycarbonyl-2-hydroxypropylamine
N-Boc-(R)-isopropanolamine
BOC-(R)-(-)-1-AMINO-2-PROPANOL
N-Boc-(R)-2-hydroxypropanamine
(R)-tert-Butyl 2-hydroxypropylcarbaMate
tert-Butyl (R)-2-hydroxy-1-propylcarbamate
(R)-1-(Boc-amino)-2-propanol, 98%
YNJCFDAODGKHAV-ZCFIWIBFSA-N
t-butyl (2R)-2-hydroxypropylcarbamate
(R)-tert-butyl(2-hydroxypropyl)carbamate

MDL Number

MFCD04974338

Customs Code

2924199090

FAQ

What are the physical and chemical properties of tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4)?

Tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4) is a colorless to slightly yellow oily liquid at room temperature. Its molecular weight is approximately 202.24 g/mol. It is slightly soluble in water and miscible with organic solvents. It is reactive towards nucleophiles and can undergo hydrolysis under basic conditions.

How is tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4) typically synthesized?

Tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4) is typically synthesized by the reaction of tert-butyl isocyanate with 2-hydroxypropylamine. The reaction is catalyzed by a basic compound such as triethylamine and proceeds with good yield and selectivity.

What industries use tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4)?

Tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4) is used in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients. It is also utilized in the polymer industry for improving the properties of polymers and in the manufacturing of sensors and semiconductors.

What precautions should be taken when handling tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4)?

When handling tert-butyl N-[(2R)-2-hydroxypropyl]carbamate (CAS: 119768-44-4), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately and safely according to the Material Safety Data Sheet (MSDS/SDS).