Baricitinib | CAS No. 1187594-09-7

Baricitinib

Basic Information

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CAS Number

1187594-09-7

Molecular Formula

C16H17N7O2S

Molecular Weight

371.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CCS(=O)(=O)N1CC(CC#N)(C1)n2cc(cn2)c3ncnc4[nH]ccc34

InChI

InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

InChIKey

XUZMWHLSFXCVMG-UHFFFAOYSA-N

LogP

2.11438

Complexity

678

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

Baricitinib (INCB28050, LY3009104)
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Baricitinib
2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
Baricitinib (LY3009104, INCB028050)
JAK inhibitor
{1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile
2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
3-Azetidineacetonitrile,1-(ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)
INCB 028050
INCB-028050
LY 3009104
LY-3009104
INCB028050
LY3009104
ISP4442I3Y
INCB 28050
C16H17N7O2S
olumiant
3-AZETIDINEACETONITRILE, 1-(ETHYLSULFONYL)-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]-
Bar
Baricitinib [U

MDL Number

MFCD21608464

FAQ

What is Baricitinib (CAS: 1187594-09-7)?

Baricitinib (CAS: 1187594-09-7) is a selective Janus kinase (JAK) inhibitor with the chemical formula C19H23N5O3S. It is a white crystalline powder, known for its anti-inflammatory and immunomodulatory properties. Baricitinib works by blocking specific cytokine signaling pathways, making it effective in treating autoimmune and inflammatory diseases.

What are the main uses of Baricitinib (CAS: 1187594-09-7)?

Baricitinib (CAS: 1187594-09-7) is primarily used as a medication for conditions like rheumatoid arthritis and psoriatic arthritis, where it inhibits JAK enzymes to reduce inflammation. It also has pharmaceutical applications in treating other autoimmune disorders. In research, Baricitinib is studied for its potential in modulating immune responses and exploring new therapeutic uses.

Is Baricitinib (CAS: 1187594-09-7) safe?

Baricitinib (CAS: 1187594-09-7) is approved by regulatory agencies like the FDA and EMA for specific medical uses. While generally safe when used as directed, it may cause side effects such as infections, gastrointestinal issues, or increased bleeding risk. Proper handling, including PPE and ventilation, is recommended for laboratory use to ensure safety standards are met.

How should Baricitinib (CAS: 1187594-09-7) be stored?

Baricitinib (CAS: 1187594-09-7) should be stored in a cool, dry place at room temperature (20-25°C), away from light and moisture. It requires airtight containers and desiccated conditions to maintain stability. Avoid exposure to heat or humidity to prevent degradation of the compound.