N-Methylpropanamide

Basic Information

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CAS Number

1187-58-2

Molecular Formula

C4H9NO

Molecular Weight

87.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

−43 °C

Boiling Point

147°C/90mmHg

Refractive Index

n20/D 1.436(lit.)

SMILES

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CCC(=O)NC

InChI

InChI=1S/C4H9NO/c1-3-4(6)5-2/h3H2,1-2H3,(H,5,6)

InChIKey

QJQAMHYHNCADNR-UHFFFAOYSA-N

LogP

0.14239999999999992

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

51.5

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

InChI=1/C4H9NO/c1-3-4(6)5-2/h3H2,1-2H3,(H,5,6
2TSZ8HW6DQ
MFCD00009300
Q27255590
N-Methylpropanamide
Propanamide, N-methyl-
1187-58-2
AKOS008932989
AS-57394
N-Methylpropionamide, purum
EINECS 214-699-7
J-003880
AI3-11122
NSC54114
BRN 1737640
Propionamide, N-methyl-
DTXSID0061583
CS-0179730
D91338
NSC-54114
UNII-2TSZ8HW6DQ
N-Methylpropionsaureamid
4-04-00-00183 (Beilstein Handbook Reference)
N-Methylpropionsaureamid [German]
NS00023824
N-Methylpropionamide
propanoic acid methyl amide
METHYLPROPIONAMIDE, N-
SY016500
FT-0633433
M0488

MDL Number

MFCD00009300

Customs Code

2924199090

FAQ

What are the physical and chemical properties of N-Methylpropanamide (CAS: 1187-58-2)?

N-Methylpropanamide (CAS: 1187-58-2) is a white crystalline solid with a molecular weight of 103.12 g/mol. It has a pKa of 10.1 and is slightly soluble in water but readily soluble in organic solvents like acetone and ethanol. The compound is less reactive compared to other amides but can undergo hydrolysis under basic conditions. It has a melting point of 68-70°C and a boiling point of 165-166°C.

How is N-Methylpropanamide (CAS: 1187-58-2) typically synthesized?

N-Methylpropanamide (CAS: 1187-58-2) is commonly synthesized via the reaction of propionamide with methylamine. The reaction proceeds under basic conditions, often using sodium hydroxide, with a yield of about 75-80%. The process is carried out in an aqueous medium, and the product is isolated by recrystallization from water or ethanol.

What industries use N-Methylpropanamide (CAS: 1187-58-2)?

N-Methylpropanamide (CAS: 1187-58-2) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the production of certain antibiotics and analgesics. It is also utilized in the polymer industry for the modification of polymer properties and in the production of sensors for detecting specific chemical species. Additionally, it plays a role in the semiconductor industry as a surface treatment agent.

What precautions should be taken when handling N-Methylpropanamide (CAS: 1187-58-2)?

When handling N-Methylpropanamide (CAS: 1187-58-2), it is important to follow standard safety procedures. Wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to avoid inhalation of vapors. Store the compound in a cool, dry place away from direct sunlight and ignition sources. In case of spills, neutralize with a suitable acid or base and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.