N-Methylpropanamide(CAS: 1187-58-2)

N-Methylpropanamide (CAS: 1187-58-2) is a white crystalline solid with a molecular weight of 103.12 g/mol. It has a pKa of 10.1 and is slightly soluble in water but readily soluble in organic solvents like acetone and ethanol. The compound is less reactive compared to other amides but can undergo hydrolysis under basic conditions. It has a melting point of 68-70°C and a boiling point of 165-166°C.

N-Methylpropanamide (CAS: 1187-58-2) is commonly synthesized via the reaction of propionamide with methylamine. The reaction proceeds under basic conditions, often using sodium hydroxide, with a yield of about 75-80%. The process is carried out in an aqueous medium, and the product is isolated by recrystallization from water or ethanol.

N-Methylpropanamide (CAS: 1187-58-2) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the production of certain antibiotics and analgesics. It is also utilized in the polymer industry for the modification of polymer properties and in the production of sensors for detecting specific chemical species. Additionally, it plays a role in the semiconductor industry as a surface treatment agent.

When handling N-Methylpropanamide (CAS: 1187-58-2), it is important to follow standard safety procedures. Wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure the use of a fume hood during handling to avoid inhalation of vapors. Store the compound in a cool, dry place away from direct sunlight and ignition sources. In case of spills, neutralize with a suitable acid or base and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.