(3R)-3-Pyrrolidinamine dihydrochloride

Basic Information

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CAS Number

116183-81-4

Molecular Formula

C4H12Cl2N2

Molecular Weight

159.06 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

>300°C

Boiling Point

214.5°Cat760mmHg

Water Solubility

very faint turbidity

Flash Point

83.5°C

Refractive Index

-1.1 ° (C=10, H2O)

Specific Rotation

-1.1° (c=10, H2O)

SMILES

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C1CNCC1N.Cl.Cl

InChI

InChI=1S/C4H10N2.2ClH/c5-4-1-2-6-3-4;;/h4,6H,1-3,5H2;2*1H/t4-;;/m1../s1

InChIKey

NJPNCMOUEXEGBL-RZFWHQLPSA-N

LogP

0.1505999999999999

Topological Polar Surface Area

38.05 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

44.8

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Hygroscopic

Synonyms & References

English

A1053
(R)-pyrrolidin-3-aminedihydrochloride
(3R)-pyrrolidin-3-amine;dihydrochloride
A13963
(R)-3-Aminopyrrolidine 2HCl
(3R)-3-AMINOPYRROLIDINE DIHYDROCHLORIDE
(R)-pyrrolidin-3-amine dihydrochloride
(R)-3-AMINO-PYRROLIDINE 2HCL
(R)-3-Amino-pyrrolidine dihydrochloride
(3R)-(-)-3-Aminopyrrolidine Dihydrochloride
(R)-Pyrrolidin-3-amine DiHCl
AKOS005146003
AC-3508
AS-15846
(R)-3-Aminopyrrolidine dihydrochloride
3-Pyrrolidinamine, dihydrochloride, (R)-
3-Pyrrolidinamine, hydrochloride (1:2), (3R)-
(3R)-pyrrolidin-3-amine dihydrochloride
(3R)-Pyrrolidin-3-amine--hydrogen chloride (1/2)
(R)-pyrrolidin-3-amine 2HCl
EN300-2009572
AKOS015845493
116183-81-4
NJPNCMOUEXEGBL-RZFWHQLPSA-N
(R)-(-)-3-Aminopyrrolidine dihydrochloride
AM81992
(3R)-3-pyrrolidinamine dihydrochloride
MFCD00070604
SCHEMBL1266793
(R)-(+)-3-Aminopyrrolidine 2HCl
DTXSID60542330

MDL Number

MFCD00070604

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (3R)-3-Pyrrolidinamine dihydrochloride (CAS: 116183-81-4)?

(3R)-3-Pyrrolidinamine dihydrochloride is a white to off-white crystalline powder. Its molecular weight is approximately 226.74 g/mol. It is soluble in water and ethanol. It is highly reactive and undergoes hydrolysis in aqueous solutions.

How is (3R)-3-Pyrrolidinamine dihydrochloride (CAS: 116183-81-4) typically synthesized?

(3R)-3-Pyrrolidinamine dihydrochloride is usually synthesized through the reaction of 3-pyrrolidinamine with hydrochloric acid. Common methods include microscale synthesis using a Dean-Stark apparatus to remove water and ensure high yield. The reaction is carried out under mild conditions to maintain the desired stereochemistry.

What industries use (3R)-3-Pyrrolidinamine dihydrochloride (CAS: 116183-81-4)?

(3R)-3-Pyrrolidinamine dihydrochloride is primarily used in the pharmaceutical industry as a precursor for drug synthesis. It is also found in some polymer formulations, particularly as a stabilizer. Additionally, it has applications in sensor technology and semiconductor manufacturing as a dopant.

What precautions should be taken when handling (3R)-3-Pyrrolidinamine dihydrochloride (CAS: 116183-81-4)?

When handling (3R)-3-Pyrrolidinamine dihydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats. This compound should be stored in a well-ventilated area and away from heat sources. In case of a spill, ensure the area is properly ventilated and use appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.