Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate | CAS No. 1160293-25-3

Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate

Basic Information

CAS Number

1160293-25-3

Molecular Formula

C12H10ClNO4

Molecular Weight

267.67 g/mol

AD

Basic Physical Properties

COC(=O)c1ccc2c(c1)N(C(=O)C2)C(=O)CCl

InChI

InChI=1S/C12H10ClNO4/c1-18-12(17)8-3-2-7-5-10(15)14(9(7)4-8)11(16)6-13/h2-4H,5-6H2,1H3

InChIKey

XTJVECSKUSTBFN-UHFFFAOYSA-N

LogP

1.1277

Topological Polar Surface Area

63.68 Ų

Hydrogen Bond Donor/Acceptor

0 / 5

Synonyms & References

English

  • methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate
  • 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
  • 1H-Indole-6-carboxylic acid, 1-(2-chloroacetyl)-2,3-dihydro-2-oxo-, methyl ester

MDL Number

MFCD23134702

FAQ

What regulatory guidelines apply to Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate (CAS: 1160293-25-3)?

Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate (CAS: 1160293-25-3) falls under various regulatory guidelines. It is classified under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a hazardous substance due to its potential to cause skin and eye irritation. In the European Union, it is regulated under REACH, requiring suppliers to provide safety data sheets (SDS) and register substances if they exceed the tonnage threshold. Additionally, the FDA and EPA may regulate its use and disposal in the United States to ensure public safety and environmental protection.

Are there alternatives to Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate in synthesis?

Alternative reagents to Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate in synthesis may include other indole derivatives or similar compounds that can achieve similar reactions. Common substitutes include methyl chloroacetate or other acyl chlorides, which can be used in similar condensation reactions. However, the choice of alternative should be based on the specific reaction conditions and desired product profile, considering factors such as cost, availability, and environmental impact.

What is the market or research trend for Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate (CAS: 1160293-25-3)?

The market for Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate (CAS: 1160293-25-3) is driven by its applications in medicinal chemistry and organic synthesis. Research trends indicate a focus on its use in developing novel drugs and chemical intermediates. Market dynamics suggest increasing demand from pharmaceutical companies. However, due to its hazardous nature, research and development efforts are also concentrating on safer alternatives and more efficient synthesis methods to address environmental and safety concerns.

How should waste containing Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate (CAS: 1160293-25-3) be handled?

Proper handling of waste containing Methyl 1-(chloroacetyl)-2-oxo-6-indolinecarboxylate (CAS: 1160293-25-3) involves careful collection in appropriate containers, followed by neutralization or incineration processes to ensure safety. It is crucial to follow local regulations and guidelines for hazardous waste disposal. Incineration should be conducted at a licensed facility to minimize environmental impact. Additionally, implementing proper personal protective equipment and safety measures is essential to protect handlers during waste management operations.

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