Triisopropyl phosphite | CAS No. 116-17-6

Q: What regulatory guidelines apply to Triisopropyl phosphite (CAS: 116-17-6)?

Triisopropyl phosphite (CAS: 116-17-6) falls under the scope of several regulatory guidelines. It is classified according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a flammable liquid and requires appropriate hazard communication labels. In the European Union, it is regulated under REACH for potential exposure to workers and the environment. The U.S. Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) also have specific requirements for handling, storage, and disposal, particularly in relation to its flammability and potential for vapor release.

Q: Are there alternatives to Triisopropyl phosphite (CAS: 116-17-6) in synthesis?

Triisopropyl phosphite (CAS: 116-17-6) is commonly used in organic synthesis as a phosphorus-containing reagent. Alternatives include other phosphorus compounds such as triphenyl phosphine, tributyl phosphine, and various phosphorus oxy-esters. Depending on the specific application, isopropyl or other alkyl phosphites can also be considered as alternatives. It is important to consider the reactivity, solubility, and functional group compatibility when selecting an alternative.

Q: What is the market or research trend for Triisopropyl phosphite (CAS: 116-17-6)?

The market for triisopropyl phosphite (CAS: 116-17-6) is primarily driven by its use in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and polymers. Research trends indicate increasing interest in developing more sustainable and environmentally friendly phosphorus-containing compounds. Additionally, there is growing focus on reducing the use of flammable solvents and exploring alternatives that offer similar reactivity and functionality.

Q: How should waste containing Triisopropyl phosphite (CAS: 116-17-6) be handled?

Waste containing triisopropyl phosphite (CAS: 116-17-6) should be collected in appropriate containers and stored in a well-ventilated area away from sources of ignition. Prior to disposal, the waste should be treated or neutralized to reduce its flammability and toxicity. Incineration is a common method for disposal, provided it is conducted in compliance with local regulations. Alternatively, professional waste disposal services can handle the waste in a manner that ensures environmental protection and compliance with safety standards.

Triisopropyl phosphite

Basic Information

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CAS Number

116-17-6

Molecular Formula

C9H21O3P

Molecular Weight

208.24 g/mol

Chemical Classification

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Boiling Point

63-64 °C/11 mmHg

Refractive Index

n20/D 1.411(lit.)

Vapor Pressure

<2 mmHg ( 20 °C)

SMILES

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CC(C)OP(OC(C)C)OC(C)C

InChI

InChI=1S/C9H21O3P/c1-7(2)10-13(11-8(3)4)12-9(5)6/h7-9H,1-6H3

InChIKey

SJHCUXCOGGKFAI-UHFFFAOYSA-N

LogP

3.4883000000000024

Topological Polar Surface Area

27.69 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

102

Safety Information

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GHS Hazard Pictograms

H301

H315

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

Hazard Class

Class 3 Class 3

Sensitiveness

Moisture Sensitive

Synonyms & References

English

EINECS 204-130-0
Tri-i-propylphosphite
Triisopropoxyphosphine
NSC6516
HSDB 2578
Tox21_304011
NCGC00357278-01
WLN: 1Y1 & OPOY1 & 1 & OY1 & 1
D97741
A803570
J-003395
AKOS009028942
T0610
CAS-116-17-6
DTXCID7024372
SCHEMBL217612
UNII-RJ7QU4YQUN
NSC 6516
Z104472880
Tri-2-propyl phosphite
Medronic acid impurity A, European Pharmacopoeia (EP) Reference Standard
Q27288144
Medronic Acid Imp. A (EP); Medronic Acid Impurity A
Phosphorous acid, triisopropyl ester
tris(propan-2-yl) phosphite
Triisopropyl phosphite, 95%
DTXSID9044372
CHEMBL3560028
Isopropyl phosphite, ((C3H7O)3P)
NS00002737
Tri-2-propylphosphite

MDL Number

MFCD00008874

FAQ

What regulatory guidelines apply to Triisopropyl phosphite (CAS: 116-17-6)?

Triisopropyl phosphite (CAS: 116-17-6) falls under the scope of several regulatory guidelines. It is classified according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a flammable liquid and requires appropriate hazard communication labels. In the European Union, it is regulated under REACH for potential exposure to workers and the environment. The U.S. Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) also have specific requirements for handling, storage, and disposal, particularly in relation to its flammability and potential for vapor release.

Are there alternatives to Triisopropyl phosphite (CAS: 116-17-6) in synthesis?

Triisopropyl phosphite (CAS: 116-17-6) is commonly used in organic synthesis as a phosphorus-containing reagent. Alternatives include other phosphorus compounds such as triphenyl phosphine, tributyl phosphine, and various phosphorus oxy-esters. Depending on the specific application, isopropyl or other alkyl phosphites can also be considered as alternatives. It is important to consider the reactivity, solubility, and functional group compatibility when selecting an alternative.

What is the market or research trend for Triisopropyl phosphite (CAS: 116-17-6)?

The market for triisopropyl phosphite (CAS: 116-17-6) is primarily driven by its use in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and polymers. Research trends indicate increasing interest in developing more sustainable and environmentally friendly phosphorus-containing compounds. Additionally, there is growing focus on reducing the use of flammable solvents and exploring alternatives that offer similar reactivity and functionality.

How should waste containing Triisopropyl phosphite (CAS: 116-17-6) be handled?

Waste containing triisopropyl phosphite (CAS: 116-17-6) should be collected in appropriate containers and stored in a well-ventilated area away from sources of ignition. Prior to disposal, the waste should be treated or neutralized to reduce its flammability and toxicity. Incineration is a common method for disposal, provided it is conducted in compliance with local regulations. Alternatively, professional waste disposal services can handle the waste in a manner that ensures environmental protection and compliance with safety standards.