![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH | CAS No. 115044-69-4
H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
Basic Information
CAS Number
115044-69-4
Molecular Formula
C103H185N31O24S
Molecular Weight
2273.8 g/mol
AD
Basic Physical Properties
Synonyms & References
English
- CaM kinase II (290-309)
- L-Alanine, L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-threonyl-L-threonyl-L-methionyl-L-leucyl-
- 115044-69-4
- Calmodulin-dependent protein kinase ii(290-309)
- MFCD00076719
- Calmodulin Binding Domain - CAS 115044-69-4
- PD076359
- L-Alanine,L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-threonyl-L-threonyl-L-methionyl-L-leucyl-
- CALMODULIN-DEPENDENT PROTEIN KINASE II (281-309)
- Calmodulin-Dependent Protein Kinase II (290 - 309)
- Calmodulin-Dependent Protein Kinase II (290-309),LKKFNARRKLKGAILTTMLA
- L-Alanine,L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L...
- L-Alanine,L-leucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-asparaginyl-L-alanyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-lysylglycyl-L
- CA2+
- CALMODULIN BINDING DOMAIN
- CALMODULIN DEPENDENT PROTEIN KINASE II
- CALMODULIN-DEPENDENT PROTEIN KINASE II FRAGMENT 290-309
- CALMODULIN-DEPENDENT PROTEIN KINASE IIFR AGMENT 290
- CAM KINASE II (290-309)
- H-LEU-LYS-LYS-P
- LEU-LYS-LYS-PHE-ASN-ALA-ARG-ARG-LYS-LEU-LYS-GLY-ALA-ILE-LEU-THR-THR-MET-LEU-ALA
- LKKFNARRKLKGAILTTMLA
- CaM Kinase II (290-309), Calmodulin Antagonist
- Calmodulin-Dependent Protein Kinase II (290-309)
- CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309)
- CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II (290-309)
FAQ
What are the physical and chemical properties of H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4)?
H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4) is a cyclic heptapeptide with a molecular weight of approximately 958 Da. It crystallizes in a rhombohedral form and is soluble in water. This compound exhibits moderate reactivity, particularly towards nucleophilic attack and amide bond formation. It is stable under neutral and slightly acidic conditions but can degrade under strongly acidic or basic conditions.
How is H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4) typically synthesized?
H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4) is synthesized through solid-phase peptide synthesis (SPPS). Commonly, the Fmoc (fluorenylmethyl carbamate) method is used, with Fmoc-amino acids and HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) as a coupling reagent. The peptide is then deprotected, purified by HPLC, and characterized by mass spectrometry.
What industries use H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4)?
H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4) is primarily used in the pharmaceutical industry for its potential as a drug candidate. It also finds applications in biotechnology and research, particularly in the development of immunological and bioassay reagents. This cyclic heptapeptide is less commonly used in industries such as polymers, sensors, and semiconductors.
What precautions should be taken when handling H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4)?
When handling H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH (CAS: 115044-69-4), it is essential to wear appropriate personal protective equipment (PPE) including gloves, lab coat, and safety goggles. This compound should be stored in a closed container at a cool, dry place and away from light. Spills should be handled with care using absorbent materials, followed by thorough cleaning with water and neutralization, if necessary. Always refer to the safety data sheet (SDS) for detailed handling procedures and emergency response information.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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