N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine

Basic Information

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CAS Number

109425-51-6

Molecular Formula

C40H33N3O4

Molecular Weight

619.72 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

150-155 ºC

Density

1.2400

Water Solubility

Slightly soluble in water.

Refractive Index

97 ° (C=5, CHCl3)

Specific Rotation

+87° (c=5 in chloroform)

SMILES

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C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)CC(C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57

InChI

InChI=1S/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-43(27-41-31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/t37-/m0/s1

InChIKey

XXMYDXUIZKNHDT-QNGWXLTQSA-N

LogP

7.257700000000007

Topological Polar Surface Area

93.45 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

967

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Moisture Sensitive

Synonyms & References

English

EN300-96350
M03415
Na-Fmoc-Nim-trityl-L-histidine
A-Fmoc-N-im-trityl-L-histidine
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-(triphenylmethyl)-
AS-12883
MFCD00043332
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-im-trityl-L-histidine
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[1-[tri(phenyl)methyl]imidazol-4-yl]propanoic acid
CS-W011428
Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-Nt-trityl-L-histidine
NS00005970
AM81823
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanoicacid
109425-51-6
XXMYDXUIZKNHDT-QNGWXLTQSA-N
Nalpha-Fmoc-Nim-trityl-L-histidine
F0653
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid
Fmoc-His(Trt)-OH, >=98.0% (sum of enantiomers, HPLC)
Fmoc-His(Trt)-OH
Nalpha-Fmoc-tele-trityl-L-histidine
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tau-(triphenylmethyl)-L-histidine
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-tele-(triphenylmethyl)-L-histidine
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
DTXSID80465310
FmocHis(Trt)OH
SCHEMBL1737899
AKOS015924157
HY-W010712

MDL Number

MFCD00043332

FAQ

What is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6) is a synthetic compound derived from L-histidine, featuring a fluorenyl group and a trityl protecting group. It is commonly used in organic synthesis and pharmaceutical research due to its stability and functional versatility. The molecule contains a carbonyl group and is characterized by its complex aromatic structure, making it suitable for applications requiring precise chemical modifications.

What are the main uses of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6) is primarily used in pharmaceutical research as an intermediate for drug development, particularly in peptide synthesis and bioconjugate applications. It also finds use in organic chemistry for functionalizing materials and in structural studies due to its unique combination of protecting groups and aromatic moieties. Its applications may include fluorescent labeling and as a scaffold for molecular design.

Is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6) safe?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6) is generally considered safe when handled according to standard laboratory protocols. However, it may cause mild irritation upon contact with skin or eyes. Safety measures include wearing gloves, safety goggles, and ensuring proper ventilation. It is not classified as highly toxic but should be treated with care to avoid exposure during handling or storage.

How should N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6) be stored?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-trityl-L-histidine (CAS: 109425-51-6) should be stored in a cool, dry place, away from light, in airtight containers to prevent moisture ingress. It is stable under standard conditions but may degrade if exposed to excessive heat or humidity. Storage at 2-8°C is recommended to maintain its chemical integrity and prolong shelf life.