Ruxolitinib phosphate

Basic Information

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CAS Number

1092939-17-7

Molecular Formula

C17H21N6O4P

Molecular Weight

115.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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OP(=O)(O)O.N#CC[C@@H](n1ncc(c1)c1ncnc2c1cc[nH]2)C1CCCC1

InChI

InChI=1S/H3N.H3O4P/c;1-5(2,3)4/h1H3;(H3,1,2,3,4)

InChIKey

LFVGISIMTYGQHF-UHFFFAOYSA-N

LogP

-0.7666000000000004

Topological Polar Surface Area

112.76 Å²

Hydrogen Bond Donor/Acceptor

6 / 5

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

INCB 018424
(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
Ruxolitinib Phosphate
(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
[14C]-Ruxolitinib phosphate
betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
Ruxolitinib Phosphat
β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(βR)-1H-Pyrazole-1-propanenitrile phosphate
(3R)-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propionitrile phosphate
INCB018424 phosphate
INCB-018424 phosphate
Ruxolitinib
Ruxolitinib phosphate
(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
phosphate (1:1)

MDL Number

MFCD18452860

Customs Code

2933990090

FAQ

What is Ruxolitinib phosphate (CAS: 1092939-17-7)?

Ruxolitinib phosphate (CAS: 1092939-17-7) is a pharmaceutical compound primarily used as an inhibitor of Janus kinase (JAK) enzymes. It has the chemical formula C21H26N4O9P and is known for its role in treating certain blood disorders, such as myelofibrosis and polycythemia vera. It is a white to off-white solid with good solubility in water and is commonly used in clinical trials and therapeutic applications.

What are the main uses of Ruxolitinib phosphate (CAS: 1092939-17-7)?

Ruxolitinib phosphate (CAS: 1092939-17-7) is mainly used in the treatment of myeloproliferative neoplasms, including myelofibrosis and polycythemia vera. It functions as a JAK1/JAK2 inhibitor, helping to reduce inflammation and modulate immune responses. Additionally, it is utilized in research for studying JAK-STAT signaling pathways and may have potential applications in other therapeutic areas such as oncology and autoimmune diseases.

Is Ruxolitinib phosphate (CAS: 1092939-17-7) safe?

Ruxolitinib phosphate (CAS: 1092939-17-7) is considered safe when used as directed in medical and research settings. However, it should be handled with care, and protective measures such as gloves and goggles are recommended to minimize exposure. Safety standards are in place for its use in pharmaceutical applications, and it is subject to regulatory guidelines to ensure proper handling and administration.

How should Ruxolitinib phosphate (CAS: 1092939-17-7) be stored?

Ruxolitinib phosphate (CAS: 1092939-17-7) should be stored in a cool, dry, and dark place, preferably at 2–8°C. It should be kept in a sealed container to prevent moisture exposure and maintain stability. Avoiding prolonged exposure to light and high humidity is essential to preserve its chemical integrity and effectiveness over time.