2-Methylpyridine

Basic Information

View in Editor

CAS Number

109-06-8

Molecular Formula

C6H7N

Molecular Weight

93.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

−70 °C

Boiling Point

128-129 °C

Water Solubility

MISCIBLE

Solubility

H2O: freely soluble

Refractive Index

n20/D 1.500(lit.)

Vapor Pressure

10 mmHg ( 24.4 °C)

SMILES

View in Editor

Cc1ccccn1

InChI

InChI=1S/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3

InChIKey

BSKHPKMHTQYZBB-UHFFFAOYSA-N

LogP

1.39002

pKa

5.97(at 20℃)

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

52.1

Safety Information

View Safety Information

GHS Hazard Pictograms

H226

H302

H312

H319

H332

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Stability

Stable. Flammable. Incompatible with strong oxidizing agents, sulfuric acid, acids, metals, iron (II) sulfate, hydrogen peroxide. Hygroscopic.

Sensitiveness

Hygroscopic

Explosive Limit

1.4-8.6%(V)

Toxicity

LD50 orally in rats: 1.41 g/kg (Smyth)

Synonyms & References

English

2-Methylpyridine
2-picoline (alpha)
α-Methylpyridine
2-Picoline
2-methyl-pyridine
2-Picoline1000µg
ai3-2409
ALPHAP
aPicolin
a-Picoline
monomethylpyridine
o-Picoline
α-Picoline
NSC 3409
NSC-3409
ALPHA-PICOLINE
2-PICOLINE 98%
2-Picoline (2-
2-PICOLINE
2-methylpyridine

MDL Number

MFCD00006332

Customs Code

29333999

FAQ

What regulatory guidelines apply to 2-Methylpyridine (CAS: 109-06-8)?

2-Methylpyridine (CAS: 109-06-8) is classified as a flammable liquid under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). It is subject to REACH regulations in the European Union, requiring companies to register and manage the safety of chemicals. FDA and EPA also have specific guidelines for the handling, storage, and disposal of this compound to ensure public and environmental safety.

Are there alternatives to 2-Methylpyridine (CAS: 109-06-8) in synthesis?

While 2-Methylpyridine (CAS: 109-06-8) is commonly used in various syntheses, alternatives include 3-Methylpyridine and 2-ethylpyridine. These alternatives can be used in similar reactions, often requiring adjustments in reaction conditions. Other substitutes include pyridine and its derivatives, which may offer different reactivity profiles and require careful selection based on specific synthesis needs.

What is the market or research trend for 2-Methylpyridine (CAS: 109-06-8)?

The market for 2-Methylpyridine (CAS: 109-06-8) is driven by its use in pharmaceuticals, agrochemicals, and as a solvent. Research trends focus on developing more environmentally friendly synthesis methods and exploring its potential in new applications. Demand is expected to grow due to its versatile properties, although variability in prices and market availability may affect research and development efforts.

How should waste containing 2-Methylpyridine (CAS: 109-06-8) be handled?

Waste containing 2-Methylpyridine (CAS: 109-06-8) should be collected in appropriate containers and stored properly to prevent spills or leaks. It can be disposed of through incineration or professional waste disposal services that comply with local regulations. Environmental protection precautions include ensuring proper ventilation and using personal protective equipment to minimize exposure. Disposal methods must adhere to local, national, and international hazardous waste regulations to protect the environment.