N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine

Basic Information

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CAS Number

108321-39-7

Molecular Formula

C19H18N2O5

Molecular Weight

354.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

No data avaiable

Melting Point

~185 °C (dec.)

Boiling Point

678.6 ℃ at 760 mmHg

Flash Point

364.2±31.5 °C

Refractive Index

1.627

Vapor Pressure

0.0±2.2 mmHg at 25°C

Specific Rotation

11.9 º (c=1%, DMF)

SMILES

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C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC(=O)N)C(=O)O

InChI

InChI=1S/C19H18N2O5/c20-17(22)9-16(18(23)24)21-19(25)26-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16H,9-10H2,(H2,20,22)(H,21,25)(H,23,24)/t16-/m1/s1

InChIKey

YUGBZNJSGOBFOV-MRXNPFEDSA-N

LogP

1.8536999999999995

Topological Polar Surface Area

118.72000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 7

Complexity

530

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Nalpha-Fmoc-D-asparagine
A801852
(2R)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid
AC-17098
Fmoc-D-asparagine
HY-W009084
J-300048
Q-101667
A-Fmoc-D-asparagine
SCHEMBL119451
Fmoc-D-Asn-OH
D-Asparagine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-
AKOS016842929
DTXSID50426317
N-alpha-(9-Fluorenylmethyloxycarbonyl)-D-asparagine (Fmoc-D-Asn-OH)
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine
F0591
(2R)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid hydroxide
Z1227755646
MFCD00062956
AS-12711
(2R)-3-CARBAMOYL-2-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO}PROPANOIC ACID
(R)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-4-AMINO-4-OXOBUTANOIC ACID
FD21210
M03353
N-
N-A-FMOC-D-ASPARAGINE
Fmoc-D-Asn-OH, >=98.0% (HPLC)
(((9H-Fluoren-9-yl)methoxy)carbonyl)-D-asparagine
EN300-81443
AM81559

MDL Number

MFCD00062956

Customs Code

29242100

FAQ

What is N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine (CAS: 108321-39-7)?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine is a synthetic amino acid derivative with a unique fluorenylmethoxycarbonyl (Fmoc) protecting group. It is used in peptide synthesis and drug development. This compound has a molecular formula of C25H27NO5 and a molecular weight of approximately 433.53 g/mol. It is characterized by its stability and ease of coupling in solid-phase peptide synthesis.

What are the main uses of N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine (CAS: 108321-39-7)?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine is primarily used in the solid-phase synthesis of peptides. It serves as a protective group for the N-terminal amino group of asparagine during peptide assembly. Additionally, it can be utilized in medicinal chemistry and drug discovery for the development of novel therapeutic agents.

Is N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine (CAS: 108321-39-7) safe?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine is generally considered safe for laboratory use under normal conditions. However, it should be handled with care due to its chemical nature. Proper personal protective equipment (PPE) such as gloves and goggles should be worn. Spills should be cleaned up immediately, and the area should be well-ventilated. Ingestion or contact with eyes should be avoided.

How should N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine (CAS: 108321-39-7) be stored?

N~2~-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine should be stored in a cool, dry place away from direct sunlight and moisture. It should be kept in a tightly sealed container to prevent degradation. The storage temperature should not exceed 25°C, and the relative humidity should be kept below 60%. Care should be taken to avoid exposure to heat and light, as these conditions can affect the stability of the compound.