5-Methyl-1,3,4-thiadiazol-2-amine

Basic Information

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CAS Number

108-33-8

Molecular Formula

C3H5N3S

Molecular Weight

115.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

223-228 °C

Boiling Point

261.2 °C at 760 mmHg

Flash Point

111.8℃

Refractive Index

1.5800 (estimate)

SMILES

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CC1=NN=C(S1)N

InChI

InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6)

InChIKey

HMPUHXCGUHDVBI-UHFFFAOYSA-N

LogP

0.42872

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

67.2

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL282505
AMY3777
2-Methyl-5-amino-1,3,4-thiadiazole
MLS001049227
CHEMBL1288960
UNII-NC799929EM
5-Methyl-1,3,4-thiadiazol-2-ylamine
NS00005577
USAF CY-3
NCGC00246452-01
5-Methyl-1,3,4-thiadiazol-2-amine
CS-0076370
DTXSID70148347
WLN: T5NN DSJ C1 E1
W-108723
1,3,4-Thiadiazole, 2-amino-5-methyl-
F13849
amino-5-methyl 1,3,4-thiadiazole
MATD
BDBM50331847
A0874
2-Amino-5-methyl-1,3,4-thiadiazole
PS-4597
HMS2787M24
SY004265
5-methyl-2-amino-1,3,4-thiadiazole
1,4-Thiadiazol-2-amine, 5-methyl-
5-methyl-2-amino-1,3,4 -thiadiazole
1,4-Thiadiazole, 2-amino-5-methyl-
SMR000427775
NSC-526661

MDL Number

MFCD00003110

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8)?

5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8) is a colorless to white crystalline solid with a molecular weight of 140.15 g/mol. Its solubility in water is 16.4 mg/L at 25°C. It is relatively stable under normal conditions but can react with strong acids and bases. The compound is highly water-soluble and has good reactivity with various functional groups in organic synthesis.

How is 5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8) typically synthesized?

5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8) is typically synthesized by the reaction of 4-methylthiosemicarbazide with chloroacetyl chloride. The reaction proceeds with high yield and good selectivity under mild conditions. This method is widely used in industrial and academic settings.

What industries use 5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8)?

5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8) is used in various industries. It is a key ingredient in the development of pharmaceuticals, where it serves as a building block for synthesizing drugs. It is also used in the synthesis of polymers and as a component in sensors and semiconductors.

What precautions should be taken when handling 5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8)?

When handling 5-Methyl-1,3,4-thiadiazol-2-amine (CAS: 108-33-8), proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbents and proper disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.