Eplerenone | CAS No. 107724-20-9

Eplerenone

Basic Information

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CAS Number

107724-20-9

Molecular Formula

C24H30O6

Molecular Weight

414.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

234-243°C

Boiling Point

597.9°C at 760 mmHg

Solubility

DMSO: soluble2mg/mL, clear (warmed)

Specific Rotation

+5° (c=1, CHCl3)

SMILES

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CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC

InChI

InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChIKey

JUKPWJGBANNWMW-VWBFHTRKSA-N

LogP

3.124500000000002

Topological Polar Surface Area

82.2 Å²

Hydrogen Bond Donor/Acceptor

0 / 6

Complexity

907

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

<p>C24H30O6</p>
BE164415
BDBM50318300
<p>(7?,11?,17?)-9,11-Epoxy-17-hydroxy-3-o xo-pregn-4-ene-7,21-dicarboxylic acid ?-lactone methyl ester</p>
methyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
methyl (1'R,2S,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
Q423804
HMS3413K08
SC 6110
DTXCID0026094
Eplerenone [USAN]
Tox21_111746_1
SR-01000942233
EPLERENONE [VANDF]
EPLERENONE [MI]
SC-6611O
A895400
HMS3677K08
AB01274707_02
Eplerenone- Bio-X
Spiro(cyclopenta(7,8)phenanthro(4b,5-b)oxirene-7(3H),2'(3'H)-furan)-10-carboxylic acid, 2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-4a,6a-dimethyl-2,5'-dioxo-, methyl ester, (4aS,4bR,5aR,6aS,7 R,9aS,9bR,10R)-
EN300-6492952
NCGC00159559-03
Eplerenone, >=98% (HPLC)
(7?,11?,17?)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid ?-lactone methyl ester
CAS-107724-20-9
Inspra (TN)
EPLERENONE [MART.]
(+)-Eplerenone
D01115
Eplerenona

MDL Number

MFCD05662207

Customs Code

29322090

FAQ

What is Eplerenone (CAS: 107724-20-9)?

Eplerenone is a synthetic steroidal mineralocorticoid receptor antagonist, commonly used in medicine. Its chemical formula is C21H26O4, and it is a white to off-white crystalline powder with good solubility in organic solvents. It is known for its selective action against aldosterone receptors, making it effective in managing hypertension and heart failure.

What are the main uses of Eplerenone (CAS: 107724-20-9)?

Eplerenone is primarily used as a medication for treating high blood pressure and heart failure. It is also employed in research for studying aldosterone receptor pathways and in pharmaceutical development for creating targeted therapies. Its applications extend to clinical trials and drug formulation processes.

Is Eplerenone (CAS: 107724-20-9) safe?

Eplerenone is generally considered safe when used as directed, but it should be handled with care. It is classified as a low-toxicity compound, though long-term exposure or improper handling may pose health risks. Safety standards include following proper protective measures, such as wearing gloves and goggles, and adhering to regulatory guidelines for use and disposal.

How should Eplerenone (CAS: 107724-20-9) be stored?

Eplerenone should be stored in a cool, dry, and dark place, preferably at 2-8°C. It is sensitive to moisture and light, so it should be kept in a sealed container away from direct sunlight. Proper storage conditions help maintain its chemical stability and potency over time.