Dolutegravir Sodium

Basic Information

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CAS Number

1051375-19-9

Molecular Formula

C20H18F2N3NaO5

Molecular Weight

441.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]

InChI

InChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28);/q;+1/p-1/t10-,15+;/m1./s1

InChIKey

UGWJRRXTMKRYNK-VSLILLSYSA-M

Complexity

836

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

dolutegravir sodium
Tivicay
GSK 1349572A
CHEMBL1213165
sodium (4R,12aS)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2',4,5]pyrazino[2,1-b][1,3]oxazin-7-olate
(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino-[2,1-b][1,3]oxazine-9-carboxamide sodium salt
CHEBI:76007
UNII-1Q1V9V5WYQ
Dolutegravir sodium [USAN]
GSK1349572 sodiuM salt
GSK-1349572A
sodium
sodium,(4R,12aS)-9-[(2,4-difluorophenyl)methylcarbamoyl]-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazin-7-olate
(4R,12aS)-9-[(2,4-difluorophenyl)methylcarbamoyl]-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazin-7-olate
Dol
Duluvir sodium salt
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide sodium salt (1:1)
Dolutegravir sodium salt
Dolutegravi Sodium
Dolutegravir SodiuM ( API)
Dolutegravir sodium(GSK1349572)
(4R,12AS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyri
Sodium (4R,12aS)-9-((2,4-difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazin-7-olate
Sodium;(4r,12as)-9-[(2,4-difluorophenyl)methylcarbamoyl]-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2h-pyrido[5,6]pyrazino[2,6-b][1,3]oxazin-7-olate
Dolutegravir Impurity 8
Dolutegravir (sodium)
GSK1349572A
1Q1V9V5WYQ
Tivicay (TN)
Dolut
Dolutegravir sodium

MDL Number

MFCD28405599

FAQ

What is Dolutegravir Sodium (CAS: 1051375-19-9)?

Dolutegravir Sodium (CAS: 1051375-19-9) is a sodium salt of a HIV integrase strand transfer inhibitor, used to treat HIV-1 infections. It has a chemical formula of C23H25N5NaO4S. The compound is typically colorless to white crystalline powder and is soluble in water.

What are the main uses of Dolutegravir Sodium (CAS: 1051375-19-9)?

Dolutegravir Sodium (CAS: 1051375-19-9) is primarily used as a potent antiretroviral drug to treat HIV-1 infections. It is effective in combination with other antiretroviral drugs for both initial and ongoing therapy.

Is Dolutegravir Sodium (CAS: 1051375-19-9) safe?

Dolutegravir Sodium (CAS: 1051375-19-9) is generally considered safe when used as directed. However, it may cause side effects such as nausea, headache, and dizziness. Patients should consult their healthcare provider if they experience severe or persistent side effects.

How should Dolutegravir Sodium (CAS: 1051375-19-9) be stored?

Dolutegravir Sodium (CAS: 1051375-19-9) should be stored at room temperature, between 15°C and 30°C (59°F to 86°F), in a tightly closed container, away from moisture and direct sunlight. It should be kept out of reach of children and pets.